Manteia - Molecule gene

ENSMUSG00000037921

Mus musculus

Features

Gene ID:	ENSMUSG00000037921

Biological name :	Ddx60

Synonyms :	Ddx60 / DExD/H-box helicase 60

Possible biological names infered from orthology :	Q8IY21

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	B3.1
Gene start:	61928087
Gene end:	62038244

Corresponding Affymetrix probe sets:	10571984 (MoGene1.0st) 1439114_at (Mouse Genome 430 2.0 Array) 1451777_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000070741 Ensembl peptide - ENSMUSP00000122841 Ensembl peptide - ENSMUSP00000120424 Ensembl peptide - ENSMUSP00000091197 NCBI entrez gene - 234311 See in Manteia. MGI - MGI:2384570 RefSeq - XM_017312698 RefSeq - NM_001293783 RefSeq - XM_006509393 RefSeq - XM_006509394 RefSeq Peptide - NP_001280712 swissprot - E9PZQ1 swissprot - D3YZ76 swissprot - G3X9F7 swissprot - D3Z3B3 Ensembl - ENSMUSG00000037921

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000009639	Gallus gallus
	ENSGALG00000038140	Gallus gallus
DDX60	ENSG00000137628	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Skiv2l / superkiller viralicidic activity 2-like (S. cerevisiae) / Q15477* / Ski2 like RNA helicase*	ENSMUSG00000040356	12
Q9CZU3 / Skiv2l2 / Superkiller viralicidic activity 2-like 2 / MTREX* / P42285* / Mtr4 exosome RNA helicase*	ENSMUSG00000016018	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR001650	Helicase, C-terminal
IPR011545	DEAD/DEAH box helicase domain
IPR014001	Helicase superfamily 1/2, ATP-binding domain
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0009615	response to virus	ISS
biological_process	GO:0051607	defense response to virus	IDA
biological_process	GO:1900245	positive regulation of MDA-5 signaling pathway	ISS
biological_process	GO:1900246	positive regulation of RIG-I signaling pathway	ISS
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0045111	intermediate filament cytoskeleton	ISO
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0003690	double-stranded DNA binding	ISS
molecular_function	GO:0003723	RNA binding	IDA
molecular_function	GO:0003725	double-stranded RNA binding	ISS
molecular_function	GO:0003727	single-stranded RNA binding	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sptssb^Tvrm122/Sptssb⁺ Genetic Background: involves: A * C57BL/6
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dmd^mdx/Y,Mirc37^tm1Boet/Mirc37^tm1Boet Genetic Background: involves: C57BL/10ScSn
MP:0008573	increased circulating interferon-alpha level	"increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]	Show Allelic Composition: Dmd^mdx/Y,Mirc37^tm1Boet/Mirc37^tm1Boet Genetic Background: involves: C57BL/10ScSn
MP:0008576	decreased circulating interferon-beta level	"reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]	Show Allelic Composition: Dmd^mdx/Y,Mirc37^tm1Boet/Mirc37^tm1Boet Genetic Background: involves: C57BL/10ScSn
MP:0009791	increased susceptibility to viral infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dmd^mdx/Y,Mirc37^tm1Boet/Mirc37^tm1Boet Genetic Background: involves: C57BL/10ScSn Allelic Composition: Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi},Mavs^tm1Tsse/Mavs^tm1Tsse Genetic Background: involves: 129 * C57BL/6N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr