ENSMUSG00000037922


Mus musculus

Features
Gene ID: ENSMUSG00000037922
  
Biological name :Bank1
  
Synonyms : Bank1 / B-cell scaffold protein with ankyrin repeats / Q80VH0
  
Possible biological names infered from orthology : B cell scaffold protein with ankyrin repeats 1 / Q8NDB2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 136053363
Gene end: 136326066
  
Corresponding Affymetrix probe sets: 10502335 (MoGene1.0st)   1456328_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142996
Ensembl peptide - ENSMUSP00000035484
Ensembl peptide - ENSMUSP00000142366
NCBI entrez gene - 242248     See in Manteia.
MGI - MGI:2442120
RefSeq - XM_006501484
RefSeq - NM_001033350
RefSeq - NM_001310749
RefSeq - XM_006501483
RefSeq Peptide - NP_001028522
RefSeq Peptide - NP_001297678
swissprot - B0F3S4
swissprot - Q80VH0
swissprot - A0A0G2JF26
Ensembl - ENSMUSG00000037922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BANK1ENSGALG00000012292Gallus gallus
 BANK1ENSG00000153064Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EQ32 / Pik3ap1 / phosphoinositide-3-kinase adaptor protein 1 / Q6ZUJ8*ENSMUSG0000002501722


Protein motifs (from Interpro)
Interpro ID Name
 IPR017893  DBB domain
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042113 B cell activation ISO
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0045947 negative regulation of translational initiation IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050869 negative regulation of B cell activation IGI
 biological_processGO:0051898 negative regulation of protein kinase B signaling IGI
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Zfp36l1tm1Seb/Zfp36l1tm1Seb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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