ENSMUSG00000037994


Mus musculus

Features
Gene ID: ENSMUSG00000037994
  
Biological name :Slc9b2
  
Synonyms : Q5BKR2 / Slc9b2 / Sodium/hydrogen exchanger 9B2
  
Possible biological names infered from orthology : Q86UD5 / solute carrier family 9 member B2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G3
Gene start: 135307700
Gene end: 135345387
  
Corresponding Affymetrix probe sets: 10496262 (MoGene1.0st)   1439995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142939
Ensembl peptide - ENSMUSP00000060640
Ensembl peptide - ENSMUSP00000123083
NCBI entrez gene - 97086     See in Manteia.
MGI - MGI:2140077
RefSeq - XM_006502402
RefSeq - XM_006502398
RefSeq - XM_006502399
RefSeq - XM_006502400
RefSeq - XM_006502401
RefSeq - NM_178877
RefSeq Peptide - NP_849208
swissprot - D6RDC5
swissprot - A0A0G2JEX4
swissprot - Q5BKR2
Ensembl - ENSMUSG00000037994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC9B2ENSDARG00000052700Danio rerio
 ENSGALG00000012319Gallus gallus
 Q86UD5ENSG00000164038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc9b1 / solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 / Q4ZJI4* / solute carrier family 9 member B1*ENSMUSG0000005015049


Protein motifs (from Interpro)
Interpro ID Name
 IPR006153  Cation/H+ exchanger
 IPR037072  Mitochondrial sodium/hydrogen exchnager 9B2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport ISO
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IDA
 biological_processGO:0072583 clathrin-dependent endocytosis IDA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:2001206 positive regulation of osteoclast development IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097228 sperm principal piece IMP
 cellular_componentGO:0097708 intracellular vesicle IEA
 molecular_functionGO:0010348 lithium:proton antiporter activity IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015299 solute:proton antiporter activity IEA
 molecular_functionGO:0015385 sodium:proton antiporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CD-1

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc9b2tm1.1Dgfu/Slc9b2tm1.1Dgfu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Slc9b2tm1.1Dgfu/Slc9b2tm1.1Dgfu
Genetic Background: B6.129-Slc9b2tm1.1Dgfu

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gja5tm1Paul/Gja5tm1Paul
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slc9b2tm1.1Dgfu/Slc9b2tm1.1Dgfu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Slc9b2tm1.1Dgfu/Slc9b2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Slc9b2tm1.1Dgfu/Slc9b2tm1.1Dgfu
Genetic Background: B6.129-Slc9b2tm1.1Dgfu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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