MP:0000172 | abnormal bone marrow cell number | "Increased or decreased number of cells that make up the core cavities of bones when compared to the norm" [MGI:tc] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0000223 | decreased monocyte count | "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000248 | macrocytosis | "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0000334 | decreased granulocyte number | "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0000359 | abnormal mast cell morphology | "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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MP:0002397 | abnormal bone marrow morphology | "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002413 | abnormal megakaryoblast morphology/development | "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002417 | abnormal megakaryocyte morphology/development | "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002590 | increased mean corpuscular volume | "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0002811 | macrocytic anemia | "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008973 | decreased erythroid progenitor cell number | "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0010067 | increased red blood cell distribution width | "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0013657 | abnormal blood cell morphology | "any structural anomaly of cells found in the blood" [CL:0000081] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0013697 | decreased granulocyte monocyte progenitor cell number | "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0013705 | decreased megakaryocyte-erythroid progenitor cell number | "reduced number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050] |
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Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Smim3tm1Anjm/Smim3+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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