ENSMUSG00000038121


Mus musculus

Features
Gene ID: ENSMUSG00000038121
  
Biological name :Fam210a
  
Synonyms : Fam210a / Protein FAM210A / Q8BGY7
  
Possible biological names infered from orthology : family with sequence similarity 210 member A / Q96ND0
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 68260187
Gene end: 68300333
  
Corresponding Affymetrix probe sets: 10459604 (MoGene1.0st)   1434977_at (Mouse Genome 430 2.0 Array)   1434978_at (Mouse Genome 430 2.0 Array)   1434979_at (Mouse Genome 430 2.0 Array)   1436219_at (Mouse Genome 430 2.0 Array)   1443873_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122677
Ensembl peptide - ENSMUSP00000045927
NCBI entrez gene - 108654     See in Manteia.
MGI - MGI:1914000
RefSeq - NM_153794
RefSeq - XM_006525524
RefSeq Peptide - NP_722489
swissprot - D3Z4B5
swissprot - Q8BGY7
Ensembl - ENSMUSG00000038121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fam210abENSDARG00000040186Danio rerio
 Q1MTD4ENSDARG00000035985Danio rerio
 Q5ZML6ENSGALG00000013887Gallus gallus
 Q96ND0ENSG00000177150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D8B6 / Fam210b / Protein FAM210B, mitochondrial / Q96KR6* / family with sequence similarity 210 member B*ENSMUSG0000002749517


Protein motifs (from Interpro)
Interpro ID Name
 IPR009688  Domain of unknown function DUF1279


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Epb41tm1b(KOMP)Mbp/Epb41+
Genetic Background: C57BL/6N-Epb41tm1b(KOMP)Mbp/J

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0010965 decreased compact bone volume 
Show

Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Fam210atm1c(EUCOMM)Wtsi/Fam210atm1c(EUCOMM)Wtsi,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6N * CBA * SJL

Allelic Composition: Fam210atm1b(EUCOMM)Wtsi/Fam210a+
Genetic Background: involves: BALB/cJ * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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