ENSMUSG00000038148


Mus musculus

Features
Gene ID: ENSMUSG00000038148
  
Biological name :Cldn16
  
Synonyms : Claudin-16 / Cldn16 / Q925N4
  
Possible biological names infered from orthology : Q9Y5I7
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B2
Gene start: 26463135
Gene end: 26482765
  
Corresponding Affymetrix probe sets: 10434837 (MoGene1.0st)   1420434_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110957
Ensembl peptide - ENSMUSP00000124528
NCBI entrez gene - 114141     See in Manteia.
MGI - MGI:2148742
RefSeq - NM_053241
RefSeq Peptide - NP_444471
swissprot - Q14BW2
swissprot - Q925N4
Ensembl - ENSMUSG00000038148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLDN16ENSGALG00000025821Gallus gallus
 CLDN16ENSG00000113946Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003927  Claudin-16
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0009350 decreased urine pH "increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0010107 abnormal renal reabsorption "any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorption begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0010111 abnormal renal calcium reabsorption "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

 MP:0011228 abnormal vitamin D level "any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)" [GO:0042368]
Show

Allelic Composition: Prss8fr/Prss8tm1.1Hum
Genetic Background: involves: 129/Sv * FS/EiJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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