ENSMUSG00000038216


Mus musculus

Features
Gene ID: ENSMUSG00000038216
  
Biological name :Pnmt
  
Synonyms : P40935 / phenylethanolamine-N-methyltransferase / Pnmt
  
Possible biological names infered from orthology : P11086
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98386450
Gene end: 98388181
  
Corresponding Affymetrix probe sets: 10380891 (MoGene1.0st)   1449804_at (Mouse Genome 430 2.0 Array)   1450606_at (Mouse Genome 430 2.0 Array)   1460269_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035549
NCBI entrez gene - 18948     See in Manteia.
MGI - MGI:97724
RefSeq - NM_008890
RefSeq Peptide - NP_032916
swissprot - P40935
swissprot - Q0VB50
Ensembl - ENSMUSG00000038216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR456635.1ENSDARG00000116039Danio rerio
 PNMTENSGALG00000027281Gallus gallus
 PNMTENSG00000141744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inmt / P40936 / Indolethylamine N-methyltransferase / O95050* / INMT-MINDY4* / INMT-MINDY4 readthrough (NMD candidate)*ENSMUSG0000000347733
Nnmt / O55239 / Nicotinamide N-methyltransferase / P40261*ENSMUSG0000003227133


Protein motifs (from Interpro)
Interpro ID Name
 IPR000940  Methyltransferase, NNMT/PNMT/TEMT
 IPR025820  Methyltransferase NNMT/PNMT/TEMT, conserved site
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042418 epinephrine biosynthetic process IEA
 biological_processGO:0042423 catecholamine biosynthetic process IEA
 molecular_functionGO:0004603 phenylethanolamine N-methyltransferase activity IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Catecholamine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sumo1tm1Oaj/Sumo1tm1Oaj
Genetic Background: involves: 129S7/SvEvBrd * ICR

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sumo1tm1Oaj/Sumo1tm1Oaj
Genetic Background: involves: 129S7/SvEvBrd * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fras1tm1.2Pjsc/Fras1tm1.2Pjsc
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Sumo1tm1Oaj/Sumo1tm1Oaj
Genetic Background: involves: 129S7/SvEvBrd * ICR

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dab2tm1.1Cpr/Dab2tm1.1Cpr
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Pnmttm1(cre)Xbao/Pnmttm1(cre)Xbao
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sumo1tm1Oaj/Sumo1tm1Oaj
Genetic Background: involves: 129S7/SvEvBrd * ICR

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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