ENSMUSG00000038473


Mus musculus

Features
Gene ID: ENSMUSG00000038473
  
Biological name :Nos1ap
  
Synonyms : nitric oxide synthase 1 (neuronal) adaptor protein / Nos1ap / Q9D3A8
  
Possible biological names infered from orthology : nitric oxide synthase 1 adaptor protein / O75052
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 170302668
Gene end: 170589861
  
Corresponding Affymetrix probe sets: 10359970 (MoGene1.0st)   1430442_at (Mouse Genome 430 2.0 Array)   1437485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125251
Ensembl peptide - ENSMUSP00000125687
Ensembl peptide - ENSMUSP00000124169
Ensembl peptide - ENSMUSP00000124240
NCBI entrez gene - 70729     See in Manteia.
MGI - MGI:1917979
RefSeq - NM_001109985
RefSeq - NM_027528
RefSeq Peptide - NP_001103455
RefSeq Peptide - NP_081804
swissprot - Q9D3A8
swissprot - E0CYH9
swissprot - Q3TRB6
swissprot - E9PYK5
Ensembl - ENSMUSG00000038473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nos1apaENSDARG00000078725Danio rerio
 nos1apaENSDARG00000105071Danio rerio
 ENSGALG00000041238Gallus gallus
 NOS1APENSG00000198929Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003062 regulation of heart rate by chemical signal IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030315 T-tubule IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0050998 nitric-oxide synthase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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