ENSMUSG00000038503


Mus musculus

Features
Gene ID: ENSMUSG00000038503
  
Biological name :Mesd
  
Synonyms : LRP chaperone MESD / Mesd / Q9ERE7
  
Possible biological names infered from orthology : mesoderm development LRP chaperone / Q14696
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 83884466
Gene end: 83901532
  
Corresponding Affymetrix probe sets: 10554704 (MoGene1.0st)   1416181_at (Mouse Genome 430 2.0 Array)   1436749_at (Mouse Genome 430 2.0 Array)   1444035_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114218
Ensembl peptide - ENSMUSP00000115696
Ensembl peptide - ENSMUSP00000091768
NCBI entrez gene - 67943     See in Manteia.
MGI - MGI:1891421
RefSeq - NM_023403
RefSeq Peptide - NP_075892
swissprot - Q9ERE7
swissprot - D3YVR4
swissprot - F6SWV4
Ensembl - ENSMUSG00000038503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mesdENSDARG00000063030Danio rerio
 mesdENSGALG00000006403Gallus gallus
 MESDENSG00000117899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019330  LRP chaperone MESD


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0007498 mesoderm development NAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Allelic Composition: Mesdtm2.1Bch/Mesdtm2.1Bch
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Mesdtm1Bch/Mesdtm2.1Bch
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Mesdtm2.1Bch/Tyrc-3YPSd
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Pde10atm1Smsh/Pde10atm1Smsh
Genetic Background: B6NTac.Cg-Pde10atm1Smsh

Allelic Composition: Mesdtm1Bch/Mesdtm2.1Bch
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Mesdtm2.1Bch/Tyrc-3YPSd
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0011189 small embryonic epiblast "reduced size of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Nestm1Dopa/Nestm1Dopa,Vimtm1Cba/Vimtm1Cba
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

Allelic Composition: Mesdtm2.1Bch/Mesdtm2.1Bch
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Mesdtm1Bch/Mesdtm2.1Bch
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Mesdtm2.1Bch/Tyrc-3YPSd
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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