ENSMUSG00000038517


Mus musculus

Features
Gene ID: ENSMUSG00000038517
  
Biological name :Tbkbp1
  
Synonyms : A2A9T0 / TBK1 binding protein 1 / Tbkbp1
  
Possible biological names infered from orthology : A7MCY6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 97136171
Gene end: 97151495
  
Corresponding Affymetrix probe sets: 10390336 (MoGene1.0st)   1431389_at (Mouse Genome 430 2.0 Array)   1435183_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103240
Ensembl peptide - ENSMUSP00000114460
Ensembl peptide - ENSMUSP00000112396
Ensembl peptide - ENSMUSP00000065461
Ensembl peptide - ENSMUSP00000103238
Ensembl peptide - ENSMUSP00000103239
NCBI entrez gene - 73174     See in Manteia.
MGI - MGI:1920424
RefSeq - XM_006534335
RefSeq - XM_006534336
RefSeq - XM_006534337
RefSeq - NM_198100
RefSeq Peptide - NP_932768
swissprot - Z4YKN2
swissprot - A2A9T0
swissprot - G3X9S9
swissprot - A2A9T1
Ensembl - ENSMUSG00000038517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbkbp1ENSDARG00000061473Danio rerio
 ENSGALG00000029558Gallus gallus
 ENSGALG00000044611Gallus gallus
 A7MCY6ENSG00000198933Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024581  Tbk1/Ikki binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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