ENSMUSG00000038587


Mus musculus

Features
Gene ID: ENSMUSG00000038587
  
Biological name :Akap12
  
Synonyms : Akap12 / A-kinase anchor protein 12 / Q9WTQ5
  
Possible biological names infered from orthology : A-kinase anchoring protein 12 / Q02952
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 4266380
Gene end: 4359470
  
Corresponding Affymetrix probe sets: 10367634 (MoGene1.0st)   1419706_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150261
Ensembl peptide - ENSMUSP00000035829
NCBI entrez gene - 83397     See in Manteia.
MGI - MGI:1932576
RefSeq - NM_031185
RefSeq Peptide - NP_112462
swissprot - B2RRE0
swissprot - Q9WTQ5
Ensembl - ENSMUSG00000038587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akap12bENSDARG00000055678Danio rerio
 ENSGALG00000036240Gallus gallus
 AKAP12ENSG00000131016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001573  Protein kinase A anchoring, WSK motif
 IPR018459  RII binding domain
 IPR028540  A-kinase anchor protein 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0010738 regulation of protein kinase A signaling ISO
 biological_processGO:0010739 positive regulation of protein kinase A signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0090036 regulation of protein kinase C signaling IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008179 adenylate cyclase binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030159 receptor signaling complex scaffold activity TAS
 molecular_functionGO:0051018 protein kinase A binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr8tm1Gma/Ccr8tm1Gma
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002683 delayed fertility "ability to produce live offspring occuring at a later than expected age" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0004961 increased prostate weight "greater than average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0006113 abnormal heart septum morphology "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0008975 delayed male fertility "ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0008976 delayed female fertility "ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0009380 abnormal ventral prostate morphology 
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0009381 abnormal dorsolateral prostate morphology 
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0009738 enlarged prostate gland anterior lobe "increased size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12645922, PMID:3308446]
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Allelic Composition: Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: (SJL/J x B6.129S2-Trp53tm1Tyj Nf1tm1Tyj/+ +)F1

 MP:0011951 increased cardiac stroke volume "increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
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Allelic Composition: Hoxa5tm1.1Ljea/Hoxa5tm1.1Ljea,Tg(Hoxa5-cre)447BLjea/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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