ENSMUSG00000038622


Mus musculus

Features
Gene ID: ENSMUSG00000038622
  
Biological name :Med30
  
Synonyms : Med30 / Mediator of RNA polymerase II transcription subunit 30 / Q9CQI9
  
Possible biological names infered from orthology : mediator complex subunit 30 / Q96HR3
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: C
Gene start: 52712408
Gene end: 52730564
  
Corresponding Affymetrix probe sets: 10424097 (MoGene1.0st)   1448917_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042204
NCBI entrez gene - 69790     See in Manteia.
MGI - MGI:1917040
RefSeq - NM_027212
RefSeq Peptide - NP_081488
swissprot - Q9CQI9
Ensembl - ENSMUSG00000038622
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med30ENSDARG00000101115Danio rerio
 MED30ENSGALG00000030862Gallus gallus
 MED30ENSG00000164758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021019  Mediator complex, subunit Med30, metazoa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0030567 abnormal I band morphology "any structural anomaly of the light band on each side of the Z disc (aka Z line), comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; the I band is isotropic to polarized light and contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end" [GO:0031674, https://en.wikipedia.org/wiki/Sarcomere]
Show

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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