ENSMUSG00000038712


Mus musculus

Features
Gene ID: ENSMUSG00000038712
  
Biological name :Mindy1
  
Synonyms : Mindy1 / Q76LS9 / Ubiquitin carboxyl-terminal hydrolase MINDY-1
  
Possible biological names infered from orthology : MINDY lysine 48 deubiquitinase 1 / Q8N5J2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 95281345
Gene end: 95296166
  
Corresponding Affymetrix probe sets: 10494208 (MoGene1.0st)   1426655_a_at (Mouse Genome 430 2.0 Array)   1426656_at (Mouse Genome 430 2.0 Array)   1432262_at (Mouse Genome 430 2.0 Array)   1437046_x_at (Mouse Genome 430 2.0 Array)   1437551_at (Mouse Genome 430 2.0 Array)   1438321_x_at (Mouse Genome 430 2.0 Array)   1454540_at (Mouse Genome 430 2.0 Array)   1458090_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142400
Ensembl peptide - ENSMUSP00000043910
Ensembl peptide - ENSMUSP00000102805
Ensembl peptide - ENSMUSP00000127839
NCBI entrez gene - 75007     See in Manteia.
MGI - MGI:1922257
RefSeq - XM_017319778
RefSeq - NM_133858
RefSeq - NM_199475
RefSeq - XM_006502219
RefSeq - XM_006502223
RefSeq - XM_011240261
RefSeq Peptide - NP_598619
RefSeq Peptide - NP_955769
swissprot - B7ZMR0
swissprot - Q76LS9
swissprot - A0A0G2JDK1
Ensembl - ENSMUSG00000038712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A3KQS4ENSDARG00000004866Danio rerio
 MINDY1ENSGALG00000028499Gallus gallus
 MINDY1ENSG00000143409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mindy2 / Q6PDI6 / Ubiquitin carboxyl-terminal hydrolase MINDY-2 / Q8NBR6* / MINDY lysine 48 deubiquitinase 2*ENSMUSG0000004244450


Protein motifs (from Interpro)
Interpro ID Name
 IPR007518  MINDY deubiquitinase
 IPR033979  MINDY deubiquitinase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016807 cysteine-type carboxypeptidase activity ISO
 molecular_functionGO:0036435 K48-linked polyubiquitin modification-dependent protein binding ISO
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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