ENSMUSG00000038763


Mus musculus

Features
Gene ID: ENSMUSG00000038763
  
Biological name :Alpk3
  
Synonyms : alpha kinase 3 / Alpk3
  
Possible biological names infered from orthology : Q96L96
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 81057600
Gene end: 81105612
  
Corresponding Affymetrix probe sets: 10554487 (MoGene1.0st)   1449573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102971
NCBI entrez gene - 116904     See in Manteia.
MGI - MGI:2151224
RefSeq - XM_017321936
RefSeq - NM_054085
RefSeq - XM_017321935
RefSeq Peptide - NP_473426
swissprot - D3YUT2
Ensembl - ENSMUSG00000038763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alpk3aENSDARG00000078989Danio rerio
 ALPK3ENSG00000136383Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alpk2 / Q91ZB0 / Alpha-protein kinase 2 / Q86TB3* / alpha kinase 2*ENSMUSG0000003284519


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR004166  MHCK/EF2 kinase
 IPR007110  Immunoglobulin-like domain
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010545 abnormal heart layer morphology "any structural anomaly of the laminar structure of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0010633 myocardial hypertrophy "an increase in size of the myocardium, not due to increased cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Alpk3tm1b(EUCOMM)Hmgu/Alpk3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Alpk3tm1b(EUCOMM)Hmgu/H

 MP:0011952 decreased cardiac stroke volume "reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]
Show

Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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