ENSMUSG00000039033


Mus musculus

Features
Gene ID: ENSMUSG00000039033
  
Biological name :Tasp1
  
Synonyms : Q8R1G1 / Tasp1 / taspase, threonine aspartase 1
  
Possible biological names infered from orthology : Q9H6P5 / taspase 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F3
Gene start: 139833480
Gene end: 140066805
  
Corresponding Affymetrix probe sets: 10488090 (MoGene1.0st)   1424810_at (Mouse Genome 430 2.0 Array)   1451998_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039546
Ensembl peptide - ENSMUSP00000096907
Ensembl peptide - ENSMUSP00000105706
NCBI entrez gene - 75812     See in Manteia.
MGI - MGI:1923062
RefSeq - XM_017319315
RefSeq - NM_001159640
RefSeq - NM_001159641
RefSeq - NM_175225
RefSeq - XM_017319310
RefSeq - XM_017319311
RefSeq - XM_017319312
RefSeq - XM_017319313
RefSeq - XM_017319314
RefSeq - XM_011239829
RefSeq - XM_017319309
RefSeq Peptide - NP_001153113
RefSeq Peptide - NP_780434
RefSeq Peptide - NP_001153112
swissprot - Q3UJT0
swissprot - Q8R1G1
Ensembl - ENSMUSG00000039033
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tasp1ENSDARG00000060580Danio rerio
 TASP1ENSGALG00000009057Gallus gallus
 TASP1ENSG00000089123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asrgl1 / Q8C0M9 / Isoaspartyl peptidase/L-asparaginase Isoaspartyl peptidase/L-asparaginase alpha chain Isoaspartyl peptidase/L-asparaginase beta chain / Q7L266* / asparaginase like 1*ENSMUSG0000002465425
Aga / Q64191 / N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Glycosylasparaginase alpha chain Glycosylasparaginase beta chain / P20933* / aspartylglucosaminidase*ENSMUSG0000003152119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000246  Peptidase T2, asparaginase 2
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR037464  Threonine aspartase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004569 glossopharyngeal nerve hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0004608 abnormal cervical axis morphology "any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004615 cervical vertebral transformation "homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh,Kmt2btm1Jjdh/Kmt2btm1Jjdh
Genetic Background: involves: 129X1/SvJ

 MP:0009879 abnormal arcus anterior morphology "any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cd79atm2Cgn/Cd79atm2Cgn
Genetic Background: involves: C57BL/6 * C.B-20

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr