ENSMUSG00000039114


Mus musculus

Features
Gene ID: ENSMUSG00000039114
  
Biological name :Nrn1
  
Synonyms : Neuritin / Nrn1 / Q8CFV4
  
Possible biological names infered from orthology : neuritin 1 / Q9NPD7
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.3
Gene start: 36725361
Gene end: 36735131
  
Corresponding Affymetrix probe sets: 10408689 (MoGene1.0st)   1428393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040900
Ensembl peptide - ENSMUSP00000153395
Ensembl peptide - ENSMUSP00000153173
Ensembl peptide - ENSMUSP00000153099
Ensembl peptide - ENSMUSP00000113721
NCBI entrez gene - 68404     See in Manteia.
MGI - MGI:1915654
RefSeq - XM_006516738
RefSeq - NM_153529
RefSeq Peptide - NP_705757
swissprot - A0A286YCW7
swissprot - A0A286YDV9
swissprot - D3Z4E2
swissprot - Q8CFV4
swissprot - A0A286YD56
Ensembl - ENSMUSG00000039114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrn1aENSDARG00000071860Danio rerio
 nrn1bENSDARG00000042656Danio rerio
 NRN1ENSGALG00000043041Gallus gallus
 NRN1ENSG00000124785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrn1l / Q8C4W3 / Neuritin-like protein / Q496H8* / neuritin 1 like*ENSMUSG0000004428728


Protein motifs (from Interpro)
Interpro ID Name
 IPR026144  Neuritin family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis ISO
 biological_processGO:1990138 neuron projection extension IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0002924 delayed CNS synapse formation "increase in time required to complete the process of generating connections between an axon and effector tissue or neuron " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0002946 delayed axon outgrowth "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

Allelic Composition: Nrn1tm1.2Ndiv/Nrn1tm1.2Ndiv,Tg(Thy1-EGFP)SJrs/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
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Allelic Composition: Cacna1atm1Kano/Cacna1atm1Kano,Grid2tm1(cre)Mwa/Grid2+
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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