ENSMUSG00000039130


Mus musculus

Features
Gene ID: ENSMUSG00000039130
  
Biological name :Zc3hc1
  
Synonyms : Q80YV2 / Zc3hc1 / zinc finger, C3HC type 1
  
Possible biological names infered from orthology : Q86WB0 / zinc finger C3HC-type containing 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 30366380
Gene end: 30391028
  
Corresponding Affymetrix probe sets: 10543697 (MoGene1.0st)   1426654_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110838
Ensembl peptide - ENSMUSP00000135447
Ensembl peptide - ENSMUSP00000116484
Ensembl peptide - ENSMUSP00000115433
Ensembl peptide - ENSMUSP00000079627
Ensembl peptide - ENSMUSP00000100057
NCBI entrez gene - 232679     See in Manteia.
MGI - MGI:1916023
RefSeq - XM_017321571
RefSeq - NM_001311086
RefSeq - NM_172735
RefSeq Peptide - NP_001298015
RefSeq Peptide - NP_766323
swissprot - D3Z5A4
swissprot - D3Z3D0
swissprot - H3BKM2
swissprot - D3Z0B2
swissprot - Q80YV2
Ensembl - ENSMUSG00000039130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zc3hc1ENSDARG00000062651Danio rerio
 ZC3HC1ENSGALG00000008003Gallus gallus
 Q86WB0ENSG00000091732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012935  Zinc finger, C3HC-like
 IPR013909  Nuclear-interacting partner of ALK/Rsm1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0004648 decreased thoracic vertebrae number "reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Zc3hc1tm1.2Jduy/Zc3hc1tm1.2Jduy
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
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Allelic Composition: Rrm2bGt(OST85254)Lex/Rrm2bGt(OST85254)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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