ENSMUSG00000039176


Mus musculus

Features
Gene ID: ENSMUSG00000039176
  
Biological name :Polg
  
Synonyms : Polg / polymerase (DNA directed), gamma
  
Possible biological names infered from orthology : DNA polymerase gamma, catalytic subunit / P54098
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 79446231
Gene end: 79466362
  
Corresponding Affymetrix probe sets: 10564736 (MoGene1.0st)   1423272_at (Mouse Genome 430 2.0 Array)   1423273_at (Mouse Genome 430 2.0 Array)   1437564_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119616
Ensembl peptide - ENSMUSP00000144510
Ensembl peptide - ENSMUSP00000144084
Ensembl peptide - ENSMUSP00000144035
Ensembl peptide - ENSMUSP00000143933
Ensembl peptide - ENSMUSP00000143923
Ensembl peptide - ENSMUSP00000143813
Ensembl peptide - ENSMUSP00000122286
Ensembl peptide - ENSMUSP00000073551
Ensembl peptide - ENSMUSP00000114414
NCBI entrez gene - 18975     See in Manteia.
MGI - MGI:1196389
RefSeq - XM_006540708
RefSeq - XM_011250825
RefSeq - NM_017462
RefSeq - XM_006540709
RefSeq - XM_006540710
RefSeq Peptide - NP_059490
swissprot - F6YLN2
swissprot - D6RIP1
swissprot - Q75WC0
swissprot - F7BP45
swissprot - A0A0J9YV64
swissprot - A0A0J9YUA1
swissprot - A0A0J9YU70
swissprot - A0A0J9YU03
swissprot - A0A0J9YTZ6
swissprot - A0A0J9YTR4
Ensembl - ENSMUSG00000039176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polgENSDARG00000060951Danio rerio
 ENSGALG00000034995Gallus gallus
 ENSGALG00000042610Gallus gallus
 ENSGALG00000006641Gallus gallus
 POLGENSG00000140521Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001098  DNA-directed DNA polymerase, family A, palm domain
 IPR002297  DNA-directed DNA-polymerase, family A, mitochondria
 IPR012337  Ribonuclease H-like superfamily
 IPR019760  DNA-directed DNA polymerase, family A, conserved site
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006287 base-excision repair, gap-filling IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005760 gamma DNA polymerase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pth1rtm3Hmk/Pth1rtm3Hmk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0001824 abnormal thymic involution "premature or late decline in thymic function normally associated with advancing age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pth1rtm3Hmk/Pth1rtm3Hmk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0008389 hypochromic macrocytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
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Allelic Composition: Polgtm1Jiha/Polgtm1Jiha
Genetic Background: involves: C57BL/6JJcl

Allelic Composition: Polgtm1Jiha/Polg+
Genetic Background: involves: C57BL/6JJcl

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Ccne1tm1Jro/?,Krastm3Tyj/?
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Fmn1tm1.1Zlr/Fmn1tm1.1Zlr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * ICR

 MP:0013659 abnormal erythroid lineage cell morphology "any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes" [CL:0000764]
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Allelic Composition: Polgtm1Prol/Polgtm1Prol
Genetic Background: B6J.129S7-Polgtm1Prol

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr