ENSMUSG00000039197


Mus musculus

Features
Gene ID: ENSMUSG00000039197
  
Biological name :Adk
  
Synonyms : Adenosine kinase / Adk / P55264
  
Possible biological names infered from orthology : P55263
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 21052574
Gene end: 21448569
  
Corresponding Affymetrix probe sets: 10413086 (MoGene1.0st)   1416319_at (Mouse Genome 430 2.0 Array)   1421767_at (Mouse Genome 430 2.0 Array)   1438292_x_at (Mouse Genome 430 2.0 Array)   1446068_at (Mouse Genome 430 2.0 Array)   1446675_at (Mouse Genome 430 2.0 Array)   1449641_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152928
Ensembl peptide - ENSMUSP00000153265
Ensembl peptide - ENSMUSP00000153089
Ensembl peptide - ENSMUSP00000153057
Ensembl peptide - ENSMUSP00000047665
NCBI entrez gene - 11534     See in Manteia.
MGI - MGI:87930
RefSeq - NM_134079
RefSeq - NM_001243041
RefSeq Peptide - NP_001229970
RefSeq Peptide - NP_598840
swissprot - P55264
swissprot - A0A286YCN3
swissprot - A0A286YCD7
swissprot - A0A286YD38
Ensembl - ENSMUSG00000039197
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adkaENSDARG00000039429Danio rerio
 adkbENSDARG00000095947Danio rerio
 ADKENSGALG00000005057Gallus gallus
 ADKENSG00000156110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001805  Adenosine kinase
 IPR002173  Carbohydrate/puine kinase, PfkB, conserved site
 IPR011611  Carbohydrate kinase PfkB
 IPR029056  Ribokinase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006166 purine ribonucleoside salvage IDA
 biological_processGO:0006167 AMP biosynthetic process IEA
 biological_processGO:0006169 adenosine salvage IBA
 biological_processGO:0006175 dATP biosynthetic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0044209 AMP salvage IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004001 adenosine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine salvage


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mlc1tm1.1Rhn/Mlc1tm1.1Rhn,Tg(Mlc1-tTA)#Rhn/0
Genetic Background: 129S6.Cg-Mlc1tm1.1Rhn Tg(Mlc1-tTA)#Rhn

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tenm4l7Rn3-6R/Tenm4l7Rn3-6R
Genetic Background: involves: BALB/cRl * C3H/Rl * C57BL/10Rl

 MP:0012348 decreased susceptibility to induction of seizure by inducing agent "higher threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Adktm2Bois/Adktm2Bois,Adora1tm1Bbf/Adora1tm1Bbf,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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