Manteia

ENSMUSG00000039262

Mus musculus

Features

Gene ID:	ENSMUSG00000039262

Biological name :	Prrc2b

Synonyms :	Protein PRRC2B / Prrc2b / Q7TPM1

Possible biological names infered from orthology :	proline rich coiled-coil 2B / Q5JSZ5

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	B
Gene start:	32151082
Gene end:	32234537

Corresponding Affymetrix probe sets:	10471298 (MoGene1.0st) 10471333 (MoGene1.0st) 10471335 (MoGene1.0st) 10500089 (MoGene1.0st) 1433624_at (Mouse Genome 430 2.0 Array) 1433625_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000114994 Ensembl peptide - ENSMUSP00000035734 Ensembl peptide - ENSMUSP00000064892 Ensembl peptide - ENSMUSP00000116429 Ensembl peptide - ENSMUSP00000121664 NCBI entrez gene - 227723 See in Manteia. MGI - MGI:1923304 RefSeq - XM_006497953 RefSeq - NM_001159634 RefSeq - NM_172661 RefSeq - XM_006497948 RefSeq - XM_006497949 RefSeq - XM_006497950 RefSeq - XM_006497951 RefSeq - XM_006497952 RefSeq Peptide - NP_001153106 RefSeq Peptide - NP_766249 swissprot - F6V431 swissprot - F7AYW2 swissprot - F6Q3E1 swissprot - Q7TPM1 swissprot - F8WHT3 Ensembl - ENSMUSG00000039262

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PRRC2B	ENSDARG00000079639	Danio rerio
	ENSGALG00000041505	Gallus gallus
	ENSGALG00000030256	Gallus gallus
PRRC2B	ENSG00000130723	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Prrc2c / Q3TLH4 / Protein PRRC2C / Q9Y520* / proline rich coiled-coil 2C*	ENSMUSG00000040225	32
Prrc2a / Q7TSC1 / Protein PRRC2A / P48634* / proline rich coiled-coil 2A*	ENSMUSG00000024393	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR009738	BAT2, N-terminal
IPR033184	Protein PRRC2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0030154	cell differentiation	IBA
cellular_component	GO:0005575	cellular_component	ND

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0000681	abnormal thyroid gland morphology	"anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0004846	absent skeletal muscle	"absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0004938	dilated vasculature	"stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0006093	arteriovenous malformation	"fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0006203	eye hemorrhage	"bleeding into the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0010572	persistent right dorsal aorta	"persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0010602	abnormal pulmonary valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0011697	vacuolated lens	"fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light" [MGI:llw2]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013155	decreased KLRG1+ CD8 alpha beta T cell number	"decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]	Show Allelic Composition: Ppp3r2^{tm1.1(KOMP)Vlcg}/Ppp3r2^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Ppp3r2^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013826	absent hypoglossal canal	"absence of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013835	absent hypoglossal nerve	"absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013840	absent segment of posterior cerebral artery	"absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013847	retropleural edema	"accumulation of watery or serous fluid in the retropleural space" [MGI:csmith]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013917	persistent right 6th pharyngeal arch artery		Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013953	left sided brachiocephalic trunk	"the brachiocephalic trunk arises on the left side of the body, often seen in conjunction with right aortic arch" [MGI:csmith]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust
MP:0013986	abnormal vitelline vein topology	"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]	Show Allelic Composition: Esr2^tm1.1Gust/Esr2^tm1.1Gust Genetic Background: B6J.129X1(Cg)-Esr2^tm1.1Gust

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr