ENSMUSG00000039285


Mus musculus

Features
Gene ID: ENSMUSG00000039285
  
Biological name :Azi2
  
Synonyms : 5-azacytidine-induced protein 2 / Azi2 / Q9QYP6
  
Possible biological names infered from orthology : 5-azacytidine induced 2 / Q9H6S1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F3
Gene start: 118040499
Gene end: 118069794
  
Corresponding Affymetrix probe sets: 10589982 (MoGene1.0st)   1431822_a_at (Mouse Genome 430 2.0 Array)   1448032_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122063
Ensembl peptide - ENSMUSP00000118765
Ensembl peptide - ENSMUSP00000121245
Ensembl peptide - ENSMUSP00000044350
Ensembl peptide - ENSMUSP00000114634
Ensembl peptide - ENSMUSP00000114980
Ensembl peptide - ENSMUSP00000116971
NCBI entrez gene - 27215     See in Manteia.
MGI - MGI:1351332
RefSeq - XM_011242976
RefSeq - NM_001048146
RefSeq - NM_001286507
RefSeq - NM_001286508
RefSeq - NM_013727
RefSeq - XM_006512147
RefSeq - XM_006512148
RefSeq - XM_006512149
RefSeq Peptide - NP_001041611
RefSeq Peptide - NP_001273437
RefSeq Peptide - NP_038755
RefSeq Peptide - NP_001273436
swissprot - D3Z7S3
swissprot - F7A092
swissprot - F6SY96
swissprot - Q9QYP6
Ensembl - ENSMUSG00000039285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 azi2ENSDARG00000102419Danio rerio
 AZI2ENSGALG00000011428Gallus gallus
 AZI2ENSG00000163512Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024581  Tbk1/Ikki binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0032607 interferon-alpha production IMP
 biological_processGO:0032609 interferon-gamma production IMP
 biological_processGO:0032635 interleukin-6 production IMP
 biological_processGO:0032640 tumor necrosis factor production IMP
 biological_processGO:0042110 T cell activation IMP
 biological_processGO:0044565 dendritic cell proliferation IGI
 biological_processGO:0097028 dendritic cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

Allelic Composition: Azi2tm1Aki/Azi2tm1Aki,Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic Background: Not Specified

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr1tm2.1Itl/?
Genetic Background: B6.Cg-Ryr1tm2.1Itl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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