ENSMUSG00000039458


Mus musculus

Features
Gene ID: ENSMUSG00000039458
  
Biological name :Mtmr12
  
Synonyms : Mtmr12 / Mus musculus myotubularin related protein 12 (Mtmr12), transcript variant 2, mRNA. / Q80TA6
  
Possible biological names infered from orthology : myotubularin related protein 12 / Q9C0I1
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 12205028
Gene end: 12274496
  
Corresponding Affymetrix probe sets: 10423155 (MoGene1.0st)   1434058_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041227
Ensembl peptide - ENSMUSP00000071883
Ensembl peptide - ENSMUSP00000133285
Ensembl peptide - ENSMUSP00000134293
NCBI entrez gene - 268783     See in Manteia.
MGI - MGI:2443034
RefSeq - XM_006520071
RefSeq - XM_017316630
RefSeq - NM_001356498
RefSeq - NM_172958
RefSeq Peptide - NP_001343427
RefSeq Peptide - NP_766546
swissprot - Q80TA6
swissprot - G3XA69
swissprot - G3UZ04
Ensembl - ENSMUSG00000039458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2BGG1ENSDARG00000059817Danio rerio
 MTMR12ENSGALG00000003168Gallus gallus
 MTMR12ENSG00000150712Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtmr10 / Q7TPM9 / Myotubularin-related protein 10 / Q9NXD2*ENSMUSG0000003052237
Mtmr11 / Q3V1L6 / Myotubularin-related protein 11 / A4FU01*ENSMUSG0000004593413


Protein motifs (from Interpro)
Interpro ID Name
 IPR010569  Myotubularin-like phosphatase domain
 IPR011993  PH-like domain superfamily
 IPR022587  Myotubularin-related 12-like C-terminal domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR030564  Myotubularin family
 IPR030576  Myotubularin-related protein 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0019208 phosphatase regulator activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031337 Mtm1 / Q9Z2C5 / X-linked myotubular myopathy gene 1 / Q13496* / myotubularin 1*  / complex / reaction
 ENSMUSG00000031918 Mtmr2 / Q9Z2D1 / Myotubularin-related protein 2 / Q13614*  / complex / reaction






 

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