ENSMUSG00000039518


Mus musculus

Features
Gene ID: ENSMUSG00000039518
  
Biological name :Cdsn
  
Synonyms : Cdsn / Mus musculus corneodesmosin (Cdsn), transcript variant 2, mRNA. / Q7TPC1
  
Possible biological names infered from orthology : corneodesmosin
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35552128
Gene end: 35557180
  
Corresponding Affymetrix probe sets: 10444883 (MoGene1.0st)   1435191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048596
NCBI entrez gene - 386463     See in Manteia.
MGI - MGI:3505689
RefSeq - NM_001355275
RefSeq - NM_001008424
RefSeq Peptide - NP_001008424
RefSeq Peptide - NP_001342204
swissprot - Q7TPC1
Ensembl - ENSMUSG00000039518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDSNENSG00000204539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026087  Corneodesmosin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043589 skin morphogenesis ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0030057 desmosome ISO
 molecular_functionGO:0042803 protein homodimerization activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0000385 distended hair follicles "follicles that have swollen or expanded from the skin" [J:53379]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0001241 absent cornified layer "missing the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001247 dermal cysts "abnormal membranous sacs appearing in the dermis" [J:53379]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0009793 sebaceous gland hypertrophy "increase in the bulk size of the sebum secreting glands of the hair shaft due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lbric-3J/Lbric-3J
Genetic Background: involves: A/J

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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