ENSMUSG00000039745


Mus musculus

Features
Gene ID: ENSMUSG00000039745
  
Biological name :Htatip2
  
Synonyms : HIV-1 Tat interactive protein 2 / Htatip2 / Q9Z2G9
  
Possible biological names infered from orthology : Q9BUP3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B4
Gene start: 49759115
Gene end: 49773975
  
Corresponding Affymetrix probe sets: 10553403 (MoGene1.0st)   1451814_a_at (Mouse Genome 430 2.0 Array)   1454227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082374
Ensembl peptide - ENSMUSP00000146858
NCBI entrez gene - 53415     See in Manteia.
MGI - MGI:1859271
RefSeq - NM_001146053
RefSeq - NM_016865
RefSeq - XM_006540992
RefSeq - NM_001146049
RefSeq - NM_001146050
RefSeq - NM_001146052
RefSeq - XM_006540988
RefSeq - XM_006540989
RefSeq - XM_006540990
RefSeq - XM_006540991
RefSeq Peptide - NP_001139522
RefSeq Peptide - NP_001139525
RefSeq Peptide - NP_058561
RefSeq Peptide - NP_001139521
RefSeq Peptide - NP_001139524
swissprot - Q9Z2G9
swissprot - Q3U816
Ensembl - ENSMUSG00000039745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htatip2ENSDARG00000028386Danio rerio
 ENSGALG00000002581Gallus gallus
 Q9BUP3ENSG00000109854Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000534  Semialdehyde dehydrogenase, NAD-binding
 IPR016040  NAD(P)-binding domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043068 positive regulation of programmed cell death ISO
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0051170 import into nucleus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002039 neuroblastoma "malignant neoplasm characterized by immature nerve cells of embryonic type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003570 uterine leiomyoma "a benign tumor derived from the smooth muscle tissue of the uterus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009311 duodenum adenocarcinoma "malignant neoplasm of epithelial cells in the duodenum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

 MP:0009551 urinary bladder transitional cell carcinoma "a malignant neoplasm of the transitional epithelial layer of the urinary bladder" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0014127 increased thymoma incidence "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
Show

Allelic Composition: Htatip2tm1Hx/Htatip2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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