ENSMUSG00000039804


Mus musculus

Features
Gene ID: ENSMUSG00000039804
  
Biological name :Ncoa5
  
Synonyms : Ncoa5 / Nuclear receptor coactivator 5 / Q91W39
  
Possible biological names infered from orthology : Q9HCD5
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 165000357
Gene end: 165034867
  
Corresponding Affymetrix probe sets: 10489620 (MoGene1.0st)   1424055_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046388
Ensembl peptide - ENSMUSP00000116778
Ensembl peptide - ENSMUSP00000113872
Ensembl peptide - ENSMUSP00000113166
NCBI entrez gene - 228869     See in Manteia.
MGI - MGI:2385165
RefSeq - XM_017317897
RefSeq - NM_144892
RefSeq - XM_006499369
RefSeq Peptide - NP_659141
swissprot - B7ZC24
swissprot - Q91W39
swissprot - A2A5L3
swissprot - B7ZC23
Ensembl - ENSMUSG00000039804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa5ENSDARG00000016345Danio rerio
 NCOA5ENSGALG00000007009Gallus gallus
 NCOA5ENSG00000124160Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0003682 chromatin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Il6tm1Kopf/Il6+,Ncoa5tm1Hxia/Ncoa5+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ncoa5tm1Hxia/Ncoa5+
Genetic Background: C.129(B6)-Ncoa5tm1Hxia

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ncoa5tm1Hxia/Ncoa5+
Genetic Background: C.129(B6)-Ncoa5tm1Hxia

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Il6tm1Kopf/Il6+,Ncoa5tm1Hxia/Ncoa5+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22+,Gata3tm1Jfz/Gata3tm2Gsv,Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ncoa5tm1Hxia/Ncoa5+
Genetic Background: C.129(B6)-Ncoa5tm1Hxia

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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