ENSMUSG00000040018


Mus musculus

Features
Gene ID: ENSMUSG00000040018
  
Biological name :Cox15
  
Synonyms : Cox15 / Cytochrome c oxidase assembly / Q8BJ03
  
Possible biological names infered from orthology : COX15, cytochrome c oxidase assembly homolog / Q7KZN9
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 43733254
Gene end: 43753000
  
Corresponding Affymetrix probe sets: 10467859 (MoGene1.0st)   1426693_x_at (Mouse Genome 430 2.0 Array)   1437982_x_at (Mouse Genome 430 2.0 Array)   1452146_a_at (Mouse Genome 430 2.0 Array)   1460376_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041820
NCBI entrez gene - 226139     See in Manteia.
MGI - MGI:1920112
RefSeq - NM_144874
RefSeq Peptide - NP_659123
swissprot - Q8BJ03
Ensembl - ENSMUSG00000040018
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cox15ENSDARG00000075933Danio rerio
 COX15ENSGALG00000007465Gallus gallus
 COX15ENSG00000014919Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003780  COX15/CtaA family
 IPR009003  Peptidase S1, PA clan
 IPR023754  Heme A synthase, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006784 heme a biosynthetic process ISO
 biological_processGO:0008535 respiratory chain complex IV assembly IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0070069 cytochrome complex IEA
 molecular_functionGO:0004129 cytochrome-c oxidase activity IEA
 molecular_functionGO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dicer1tm1.1Doca/Dicer1tm1.1Doca
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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