ENSMUSG00000040125


Mus musculus

Features
Gene ID: ENSMUSG00000040125
  
Biological name :Gpr26
  
Synonyms : Gpr26 / G-protein coupled receptor 26 / Q8BZA7
  
Possible biological names infered from orthology : Q8NDV2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 131966460
Gene end: 131994405
  
Corresponding Affymetrix probe sets: 10558257 (MoGene1.0st)   1440623_at (Mouse Genome 430 2.0 Array)   1444661_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041664
NCBI entrez gene - 233919     See in Manteia.
MGI - MGI:2441758
RefSeq - NM_173410
RefSeq Peptide - NP_775586
swissprot - Q0VBG4
swissprot - Q8BZA7
Ensembl - ENSMUSG00000040125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr26ENSDARG00000074389Danio rerio
 GPR26ENSGALG00000009684Gallus gallus
 GPR26ENSG00000154478Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0001987 alcohol preference 
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Ifngtm3.1Lky/Ifngtm3.1Lky
Genetic Background: B6.129S4-Ifngtm3.1Lky

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0011613 decreased circulating ghrelin level "less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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