MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000061 | fragile skeleton | "easily damaged or broken bones" [J:14208] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000074 | abnormal neurocranium morphology | "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000130 | abnormal cancellous bone morphology | "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000135 | reduced cortical bone thickness | "thinner than normal superficial layer of compact bone " [J:61509] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001533 | abnormal skeleton physiology | "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001541 | abnormal osteoclast function | "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: SucoGt(KST050)Byg/SucoGt(KST050)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0002932 | abnormal joint | "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0002968 | increased circulating alkaline phosphatase level | "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0002998 | abnormal bone remodeling | "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0002999 | abnormal bone healing | "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0003420 | delayed intramembranous bone ossification | "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0003723 | abnormal long bone morphology | "malformation of any of the several elongated bones of the extremities
" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004701 | decreased circulating insulin-like growth factor I level | "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004985 | decreased osteoclast cell number | "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004986 | abnormal osteoblast morphology | "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0005006 | abnormal osteoblast function | "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0006054 | spinal hemorrhage | "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0009346 | decreased cancellous bone thickness | "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0010933 | decreased trabecular bone connectivity density | "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: SucoGt(KST050)Byg/SucoGt(KST050)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0011642 | abnormal bone collagen fibril morphology | "any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0011711 | decreased osteoblast differentiation | |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0030029 | wide cranial sutures | "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0030279 | thin neurocranium | "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0030441 | increased osteoblast apoptosis | "increase in the number of osteoblasts undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0030482 | increased osteocyte number | "greater than average number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [MGI:anna] |
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0 Genetic Background: involves: 129 * C57BL/6 * SJL
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