ENSMUSG00000040710


Mus musculus

Features
Gene ID: ENSMUSG00000040710
  
Biological name :St8sia4
  
Synonyms : Q64692 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 / St8sia4
  
Possible biological names infered from orthology : Q92187
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 95587682
Gene end: 95667571
  
Corresponding Affymetrix probe sets: 10356880 (MoGene1.0st)   1419186_a_at (Mouse Genome 430 2.0 Array)   1430391_a_at (Mouse Genome 430 2.0 Array)   1446617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043477
Ensembl peptide - ENSMUSP00000140534
NCBI entrez gene - 20452     See in Manteia.
MGI - MGI:106018
RefSeq - XM_006529275
RefSeq - NM_001159745
RefSeq - NM_009183
RefSeq Peptide - NP_001153217
RefSeq Peptide - NP_033209
swissprot - Q53WR7
swissprot - Q64692
swissprot - A0A087WRA0
Ensembl - ENSMUSG00000040710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 st8sia4ENSDARG00000103600Danio rerio
 ST8SIA4ENSGALG00000026192Gallus gallus
 Q92187ENSG00000113532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35696 / St8sia2 / Alpha-2,8-sialyltransferase 8B / Q92186* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2*ENSMUSG0000002578958
Q64689 / St8sia3 / Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase / O43173* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3*ENSMUSG0000005681233
P70126 / St8sia5 / Alpha-2,8-sialyltransferase 8E / O15466* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5*ENSMUSG0000002542528
Q64687 / St8sia1 / Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase / Q92185* / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1*ENSMUSG0000003028327
Q8K4T1 / St8sia6 / ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 / P61647*ENSMUSG0000000341827


Protein motifs (from Interpro)
Interpro ID Name
 IPR001675  Glycosyl transferase family 29
 IPR012163  Sialyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001574 ganglioside biosynthetic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IEA
 biological_processGO:0009311 oligosaccharide metabolic process IEA
 biological_processGO:0097503 sialylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IEA
 molecular_functionGO:0008373 sialyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism
NCAM1 interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Rag1tm1Mom/Rag1tm1Mom
Genetic Background: B6.129S7-Rag1tm1Mom

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

Allelic Composition: St8sia2tm1Jxm/St8sia2tm1Jxm,St8sia4tm1.1Mifu/St8sia4tm1.1Mifu,Tg(Thy1-YFP)HJrs/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0010012 ectopic cerebral cortex pyramidal cells "the cerebral cortex pyramidal cell body resides in places other than the pyramidal cell layer of the cerebral cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Kiss1rtm1Rla/Kiss1rtm1Rla
Genetic Background: involves: 129S1/SvImJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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