MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000633 | abnormal pituitary gland morphology | "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hesx1tm1Icar/Hesx1tm2Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
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MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Hesx1tm1Icar/Hesx1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
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MP:0000787 | abnormal telencephalon morphology | "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0000837 | abnormal hypothalamus morphology | "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: B6.129S-Hesx1tm1(cre)Jpmb
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1tm2Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
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MP:0000936 | small telencephalic vesicles | "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm4.1Jpmb/Hesx1tm4.1Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1Icar/Hesx1+,Tcf7l1tm2Efu/Tcf7l1+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu Genetic Background: involves: 129S/SvEv
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1tm2Kem,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Cftrtm1.1Cwr/Cftrtm1.1Cwr Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: B6.129S-Hesx1tm1(cre)Jpmb
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm1Icar/Hesx1tm2Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm4.1Jpmb/Hesx1tm4.1Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1Icar/Hesx1+,Tcf7l1tm2Efu/Tcf7l1+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu Genetic Background: involves: 129S/SvEv
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1tm2Kem,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: B6.129S-Hesx1tm1(cre)Jpmb
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm1Icar/Hesx1tm2Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm4.1Jpmb/Hesx1tm4.1Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+ Genetic Background: involves: 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1Icar/Hesx1+,Tcf7l1tm2Efu/Tcf7l1+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu Genetic Background: involves: 129S/SvEv
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1tm2Kem,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1+ Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0002196 | acallosal | "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002233 | abnormal nose morphology | "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Hesx1tm1Icar/Hesx1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002237 | abnormal nasal cavity morphology | "any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003232 | abnormal forebrain development | "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Hesx1tm4.1Jpmb/Hesx1tm4.1Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm2Kem/Ctnnb1+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S1/Sv * 129X1/SvJ
Allelic Composition: Ctnnb1tm1Max/Ctnnb1+,Hesx1tm1Icar/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0003425 | abnormal optic vesicle formation | "anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
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MP:0004096 | abnormal midbrain-hindbrain boundary development | "anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004163 | abnormal adenophysis morphology | "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0004269 | abnormal optic cup morphology | "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0004309 | absent otic vesicle | "absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0005193 | abnormal anterior eye segment morphology | "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
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MP:0006198 | enophthalmos | "sinking or retraction of the eye back into the socket" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0006292 | abnormal olfactory placode morphology | "any structural abnormality in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes" [J:62024, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0006306 | abnormal nasal pit morphology | "malformation of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus" [J:119812, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008219 | abnormal dorsal telencephalic commissure morphology | "any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure" [PMID:16715082] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0008223 | absent hippocampal commissure | "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008225 | abnormal anterior commissure morphology | "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0008227 | absent anterior commissure | "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0008321 | small adenohypophysis | "reduced size of the anterior part of the pituitary that secretes a variety of hormones" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008789 | abnormal olfactory epithelium morphology | "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0009901 | abnormal frontonasal prominence morphology | "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0010059 | olfactory bulb hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb Genetic Background: B6.129S-Hesx1tm1(cre)Jpmb
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MP:0011759 | absent Rathke s pouch | "absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0012004 | abnormal septum pellucidum morphology | "any structural anomaly of the thin, triangular, vertical membrane separating the anterior horns of the left and righ of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala" [MGI:csmith, MPD:Molly] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0012138 | decreased forebrain size | "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Hesx1tm1(cre)Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1tm1Icar,Tcf7l1tm2Efu/Tcf7l1+ Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
Allelic Composition: Hesx1tm1(cre)Jpmb/Hesx1+,Tcf7l1tm1Efu/Tcf7l1tm2Efu Genetic Background: involves: 129S/SvEv
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MP:0012178 | absent frontonasal prominence | "absence of the unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout" [MGI:anna] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0012703 | decreased embryonic neuroepithelium thickness | "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0013342 | bifurcated Rathke s pouch | "the appearance of an abnormal division in the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed " [MGI:Anna, PMID:19074474] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0013351 | abnormal Rathke s pouch development | "any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland" [MGI:Anna] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0013356 | ectopic pituitary gland | "a pituitary gland located outside of its normal position" [MGI:Anna] |
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Allelic Composition: Hesx1tm2Jpmb/Hesx1tm2Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0013357 | ectopic adenohypophysis | "an anterior pituitary gland located outside of its normal position due to arrest of migration from a pharyngeocranial location to the sellar region; a portion or all of the adenohypophysis may persist in the pathway of the pharyngeal pouch, either in the nasopharyngeal wall or within the sphenoid bone" [MGI:Anna, PMID:19093031] |
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N
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MP:0013597 | small vomeronasal organ | "reduced size of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, MGI:csmith] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0014198 | absent pituitary infundibular stalk | "absence of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland" [MGI:Anna] |
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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