ENSMUSG00000040936


Mus musculus

Features
Gene ID: ENSMUSG00000040936
  
Biological name :Ulk4
  
Synonyms : Q3V129 / Ulk4 / unc-51-like kinase 4
  
Possible biological names infered from orthology : Q96C45
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F4
Gene start: 120955351
Gene end: 121277197
  
Corresponding Affymetrix probe sets: 10597775 (MoGene1.0st)   1431319_at (Mouse Genome 430 2.0 Array)   1436628_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129214
Ensembl peptide - ENSMUSP00000131488
Ensembl peptide - ENSMUSP00000131342
Ensembl peptide - ENSMUSP00000054833
Ensembl peptide - ENSMUSP00000057960
NCBI entrez gene - 209012     See in Manteia.
MGI - MGI:1921622
RefSeq - XM_006512022
RefSeq - XM_006512024
RefSeq - XM_006512025
RefSeq - XM_011242952
RefSeq - XM_017313263
RefSeq - XM_006512023
RefSeq - NM_177589
RefSeq Peptide - NP_808257
swissprot - Q3V129
swissprot - E9Q2P5
swissprot - H7BX20
swissprot - E9Q220
swissprot - E9QKJ7
Ensembl - ENSMUSG00000040936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX511115.1ENSDARG00000104558Danio rerio
 ulk4ENSDARG00000004176Danio rerio
 ENSGALG00000036110Gallus gallus
 ENSGALG00000039440Gallus gallus
 ENSGALG00000033698Gallus gallus
 ULK4ENSG00000168038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010975 regulation of neuron projection development ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0043408 regulation of MAPK cascade ISO
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0046328 regulation of JNK cascade ISO
 biological_processGO:0090036 regulation of protein kinase C signaling ISO
 biological_processGO:1900744 regulation of p38MAPK cascade ISO
 biological_processGO:2001222 regulation of neuron migration ISO
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000917 obstructive hydrocephaly "hydrocephaly due to a block in cerebralspinal fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0001866 nasal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0002691 small stomach "reduced size of the stomach" [J:77398, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009716 abnormal subcommissural organ morphology "any structural anomaly of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin" [MESH:A08.713.810]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0010152 abnormal brain ependyma morphology "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011057 absent brain ependyma motile cilia "absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0013907 abnormal cerebrospinal fluid flow "any anomaly in the dynamic process by which CSF circulates from the sites of secretion to the sites of absorption according to a unidirectional rostrocaudal flow in ventricular cavities and a multidirectional flow in subarachnoid spaces; CSF produced by the choroid plexuses in the lateral ventricles travels through interventricular foramina to the third ventricle, and then the fourth ventricle via the cerebral aqueduct and finally to the subarachnoid spaces via the median aperture (foramen of Magendie) of the fourth ventricle; in the cranial subarachnoid space, CSF circulates rostrally to the villous sites of absorption or caudally to the spinal subarachnoid space; CSF circulation through the ventricular system is driven by motile cilia on ependymal cells of the brain; CSF flow is pulsatile, corresponding to the systolic pulse wave in choroidal arteries; additional factors such as respiratory waves, the subject s posture, jugular venous pressure and physical effort also modulate CSF flow dynamics and pressure" [MGI:Anna, PMID:22100360, PMID:24229449]
Show

Allelic Composition: Ulk4tm1a(KOMP)Wtsi/Ulk4tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0030113 maxillary sinus inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the maxillary sinuses" [MGI:anna]
Show

Allelic Composition: Cd40lgm1Btlr/Y
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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