ENSMUSG00000041361


Mus musculus

Features
Gene ID: ENSMUSG00000041361
  
Biological name :Myzap
  
Synonyms : Myocardial zonula adherens protein / Myzap / Q3UIJ9
  
Possible biological names infered from orthology : GCOM1 / GRINL1A complex locus 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: D
Gene start: 71504347
Gene end: 71592360
  
Corresponding Affymetrix probe sets: 10594840 (MoGene1.0st)   1455180_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091342
Ensembl peptide - ENSMUSP00000131906
Ensembl peptide - ENSMUSP00000131643
Ensembl peptide - ENSMUSP00000127028
NCBI entrez gene - 102371     See in Manteia.
MGI - MGI:2142908
RefSeq - NM_001033208
RefSeq Peptide - NP_001028380
swissprot - E9Q4R0
swissprot - E9PWY8
swissprot - E9Q565
swissprot - Q3UIJ9
Ensembl - ENSMUSG00000041361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myzapENSDARG00000075017Danio rerio
 ENSGALG00000036680Gallus gallus
 GCOM1ENSG00000137878Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcom1 / GRINL1A complex locus 1*ENSMUSG0000009213794
Tuft1 / O08970 / tuftelin 1 / Q9NNX1*ENSMUSG0000000596819
Ccdc68 / Q8BVC4 / Coiled-coil domain-containing protein 68 / Q9H2F9* / coiled-coil domain containing 68*ENSMUSG0000003890317
Q6P6I6 / Polr2m / polymerase (RNA) II (DNA directed) polypeptide M / Q6EEV4* / P0CAP2* / RNA polymerase II subunit M*ENSMUSG000000321997


Protein motifs (from Interpro)
Interpro ID Name
 IPR028273  Myocardial zonula adherens protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031674 I band IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

 MP:0010630 abnormal cardiac muscle tissue morphology "any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pou2f1tm1Shrp/Pou2f1+,Sox2tm1.1Vep/Sox2+
Genetic Background: involves: 129S4/SvJae * C3H/HeN * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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