ENSMUSG00000041523


Mus musculus

Features
Gene ID: ENSMUSG00000041523
  
Biological name :Upk2
  
Synonyms : Upk2 / uroplakin 2
  
Possible biological names infered from orthology : O00526
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44452715
Gene end: 44454976
  
Corresponding Affymetrix probe sets: 10592878 (MoGene1.0st)   1421781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040481
NCBI entrez gene - 22269     See in Manteia.
MGI - MGI:98913
RefSeq - NM_009476
RefSeq Peptide - NP_033502
swissprot - Q3SXK0
Ensembl - ENSMUSG00000041523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UPK2ENSG00000110375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009952  Uroplakin-2
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030855 epithelial cell differentiation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0003587 ureter obstruction "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0003630 abnormal urothelium "malformation of the mucus lining in organs of the urinary tract, consisting in the bladder of three to seven cell layers" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95622]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0011424 decreased urine uric acid level "abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Cblbtm1Pngr/Cblbtm1Pngr,Vav1tm1Tyb/Vav1tm1Tyb,Wastm1Sbs/Wastm1Sbs
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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