Manteia - Molecule gene

ENSMUSG00000041740

Mus musculus

Features

Gene ID:	ENSMUSG00000041740

Biological name :	Rnf10

Synonyms :	Q3UIW5 / RING finger protein 10 / Rnf10

Possible biological names infered from orthology :	Q8N5U6

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	115241412
Gene end:	115272898

Corresponding Affymetrix probe sets:	10532965 (MoGene1.0st) 1423102_a_at (Mouse Genome 430 2.0 Array) 1456689_at (Mouse Genome 430 2.0 Array) 1459209_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041778 Ensembl peptide - ENSMUSP00000107725 Ensembl peptide - ENSMUSP00000107726 Ensembl peptide - ENSMUSP00000131696 NCBI entrez gene - 50849 See in Manteia. MGI - MGI:1859162 RefSeq - XM_017320970 RefSeq - NM_001302448 RefSeq - NM_001302449 RefSeq - NM_016698 RefSeq - XM_006530404 RefSeq Peptide - NP_001289378 RefSeq Peptide - NP_057907 RefSeq Peptide - NP_001289377 swissprot - Q3UIW5 swissprot - H7BX06 swissprot - D3Z1N2 swissprot - F7AN16 Ensembl - ENSMUSG00000041740

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rnf10	ENSDARG00000079687	Danio rerio
RNF10	ENSGALG00000036417	Gallus gallus
RNF10	ENSG00000022840	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR017907	Zinc finger, RING-type, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0010626	negative regulation of Schwann cell proliferation	ISS
biological_process	GO:0031643	positive regulation of myelination	ISS
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISS
biological_process	GO:0051865	protein autoubiquitination	ISO
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	ISO
molecular_function	GO:0044212	transcription regulatory region DNA binding	ISS
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H Allelic Composition: Rnf10^{tm1a(KOMP)Wtsi}/Rnf10^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1a(KOMP)Wtsi}/Wtsi
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Rhobtb3^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Rhobtb3^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay
MP:0001401	jumpy	"marked by fitful, jerky movements" [J:22295]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Rnf10^{tm1a(KOMP)Wtsi}/Rnf10^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1a(KOMP)Wtsi}/Wtsi
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Rhobtb3^{tm1a(KOMP)Wtsi}/Wtsi
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0002574	increased vertical activity	"greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc
MP:0002966	decreased circulating alkaline phosphatase level	"reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0003382	straub tail	"condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0003795	abnormal bone structure		Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rnf10^{tm1a(KOMP)Wtsi}/Rnf10^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1a(KOMP)Wtsi}/Rnf10^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H
MP:0005419	hypoalbuminemia	"blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0005543	corneal thinning	"decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0005554	decreased circulating creatinine level	"less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0005567	decreased circulating total protein level	"less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0005599	increased cardiac muscle contractility	"greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005633	increased circulating sodium level	"greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0005642	decreased mean corpuscular hemoglobin concentration	"less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc
MP:0008044	increased NK cell number	"greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi
MP:0008181	increased marginal zone B cell number	"greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0009142	decreased prepulse inhibition	"decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/H Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/J
MP:0011965	decreased total retina thickness	"decreased width of the retina through the center plane" [MGI:csmith]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ics
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Ucd
MP:0013678	decreased Ly6C-positive NK T cell number	"reduction in the number of NK T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Rnf10^{tm1b(KOMP)Wtsi}/Rnf10^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Rnf10^{tm1b(KOMP)Wtsi}/Rbrc

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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