ENSMUSG00000041986


Mus musculus

Features
Gene ID: ENSMUSG00000041986
  
Biological name :Elmod1
  
Synonyms : Elmod1 / ELMO domain-containing protein 1 / Q3V1U8
  
Possible biological names infered from orthology : ELMO domain containing 1 / Q8N336
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 53911457
Gene end: 53975301
  
Corresponding Affymetrix probe sets: 10593634 (MoGene1.0st)   1434083_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046191
Ensembl peptide - ENSMUSP00000129082
NCBI entrez gene - 270162     See in Manteia.
MGI - MGI:3583900
RefSeq - XM_006511207
RefSeq - NM_177769
RefSeq - XM_006511205
RefSeq - XM_006511206
RefSeq Peptide - NP_808437
swissprot - E9Q0K9
swissprot - Q3V1U8
Ensembl - ENSMUSG00000041986
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elmod1ENSDARG00000062056Danio rerio
 ELMOD1ENSGALG00000017169Gallus gallus
 ELMOD1ENSG00000110675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elmod2 / Q8BGF6 / ELMO domain-containing protein 2 / Q8IZ81* / ELMO domain containing 2*ENSMUSG0000003515147


Protein motifs (from Interpro)
Interpro ID Name
 IPR006816  ELMO domain
 IPR030722  ELMO domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0001486 abnormal startle reflex "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Elk4tm1a(EUCOMM)Wtsi/Elk4tm1a(EUCOMM)Wtsi
Genetic Background: Not Specified

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ehmt1tm1b(EUCOMM)Hmgu/Ehmt1+
Genetic Background: C57BL/6N-Ehmt1tm1b(EUCOMM)Hmgu/Nju

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

Allelic Composition: Elmod1tm1b(EUCOMM)Hmgu/Elmod1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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