ENSMUSG00000042148


Mus musculus

Features
Gene ID: ENSMUSG00000042148
  
Biological name :Cox10
  
Synonyms : Cox10 / Protoheme IX farnesyltransferase, mitochondrial / Q8CFY5
  
Possible biological names infered from orthology : COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor / Q12887
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 63962627
Gene end: 64079468
  
Corresponding Affymetrix probe sets: 10386955 (MoGene1.0st)   1429329_at (Mouse Genome 430 2.0 Array)   1435380_at (Mouse Genome 430 2.0 Array)   1459977_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040138
NCBI entrez gene - 70383     See in Manteia.
MGI - MGI:1917633
RefSeq - NM_178379
RefSeq Peptide - NP_848466
swissprot - Q3U3N1
swissprot - Q8CFY5
Ensembl - ENSMUSG00000042148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cox10ENSDARG00000034309Danio rerio
 COX10ENSGALG00000001375Gallus gallus
 COX10ENSG00000006695Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000537  UbiA prenyltransferase family
 IPR006369  Protohaem IX farnesyltransferase
 IPR016315  Protohaem IX farnesyltransferase, mitochondria
 IPR030470  UbiA prenyltransferase conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IMP
 biological_processGO:0006783 heme biosynthetic process IEA
 biological_processGO:0006784 heme a biosynthetic process ISO
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0008535 respiratory chain complex IV assembly IEA
 biological_processGO:0009060 aerobic respiration IMP
 biological_processGO:0017004 cytochrome complex assembly IDA
 biological_processGO:0018343 protein farnesylation ISO
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0045333 cellular respiration IEA
 biological_processGO:0048034 heme O biosynthetic process IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0070069 cytochrome complex ISO
 molecular_functionGO:0004129 cytochrome-c oxidase activity IEA
 molecular_functionGO:0004311 farnesyltranstransferase activity IBA
 molecular_functionGO:0008495 protoheme IX farnesyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups IEA


Pathways (from Reactome)
Pathway description
Heme biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0003646 muscle fatigue "increased muscle exhaustion or increased susceptibility to muscle exhaustion" [J:96306]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0004167 abnormal cingulate gyrus morphology "any malformation or absence of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Myl1tm1(cre)Sjb/Myl1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010009 abnormal piriform cortex morphology 
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
Show

Allelic Composition: Cox10tm1Ctm/Cox10tm1Ctm,Slc6a3tm1.1(cre)Bkmn/?
Genetic Background: B6.Cg-Cox10tm1Ctm Slc6a3tm1.1(cre)Bkmn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr