ENSMUSG00000042272


Mus musculus

Features
Gene ID: ENSMUSG00000042272
  
Biological name :Sestd1
  
Synonyms : Q80UK0 / SEC14 domain and spectrin repeat-containing protein 1 / Sestd1
  
Possible biological names infered from orthology : Q86VW0 / SEC14 and spectrin domain containing 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C3
Gene start: 77180340
Gene end: 77280592
  
Corresponding Affymetrix probe sets: 10484227 (MoGene1.0st)   1429114_at (Mouse Genome 430 2.0 Array)   1455549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099720
Ensembl peptide - ENSMUSP00000099721
NCBI entrez gene - 228071     See in Manteia.
MGI - MGI:1916262
RefSeq - XM_017317597
RefSeq - NM_175465
RefSeq - XM_006499202
RefSeq - XM_011239447
RefSeq - XM_006499200
RefSeq - XM_006499201
RefSeq Peptide - NP_780674
swissprot - Q80UK0
Ensembl - ENSMUSG00000042272
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SX85ENSDARG00000040614Danio rerio
 SESTD1ENSGALG00000009031Gallus gallus
 Q86VW0ENSG00000187231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
 cellular_componentGO:0034704 calcium channel complex ISO
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding ISO
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding ISO
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding ISO
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding ISO
 molecular_functionGO:0070300 phosphatidic acid binding ISO
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0003936 abnormal reproductive system development "developmental anomaly of any of the organs involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0003942 abnormal urinary system development 
Show

Allelic Composition: Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr

 MP:0008999 absent anus "absence of the lower opening of the digestive tract" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0009252 absent urinary bladder "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

 MP:0011771 abnormal genital tubercle morphology "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [MGI:anna]
Show

Allelic Composition: Prkcitm1.1Rfar/Prkcitm1.1Rfar
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * NMRI

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1tm1.1Bnrc,Sestd1tm1.1Bnrc/Sestd1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Dact1tm1.1Bnrc/Dact1+,Sestd1tm1.1Bnrc/Sestd1tm1.1Bnrc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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