ENSMUSG00000042650


Mus musculus

Features
Gene ID: ENSMUSG00000042650
  
Biological name :Alkbh5
  
Synonyms : Alkbh5 / Q3TSG4 / RNA demethylase ALKBH5
  
Possible biological names infered from orthology : alkB homolog 5, RNA demethylase / Q6P6C2
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 60536381
Gene end: 60558512
  
Corresponding Affymetrix probe sets: 10376685 (MoGene1.0st)   1434701_at (Mouse Genome 430 2.0 Array)   1437728_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049116
NCBI entrez gene - 268420     See in Manteia.
MGI - MGI:2144489
RefSeq - NM_172943
RefSeq Peptide - NP_766531
swissprot - Q3TSG4
Ensembl - ENSMUSG00000042650
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkbh5ENSDARG00000063003Danio rerio
 ALKBH5ENSGALG00000043693Gallus gallus
 ALKBH5ENSG00000091542Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027450  Alpha-ketoglutarate-dependent dioxygenase AlkB-like
 IPR032860  RNA demethylase ALKBH5
 IPR037151  Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006397 mRNA processing ISO
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035553 oxidative single-stranded RNA demethylation ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0035515 oxidative RNA demethylase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Reversal of alkylation damage by DNA dioxygenases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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