ENSMUSG00000042682


Mus musculus

Features
Gene ID: ENSMUSG00000042682
  
Biological name :Selenok
  
Synonyms : Q9JLJ1 / Selenok / Selenoprotein K
  
Possible biological names infered from orthology : Q9Y6D0
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 29968308
Gene end: 29975662
  
Corresponding Affymetrix probe sets: 10405729 (MoGene1.0st)   10413497 (MoGene1.0st)   1423225_at (Mouse Genome 430 2.0 Array)   1447909_s_at (Mouse Genome 430 2.0 Array)   1447910_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153053
Ensembl peptide - ENSMUSP00000107887
NCBI entrez gene - 80795     See in Manteia.
MGI - MGI:1931466
RefSeq - NM_019979
RefSeq Peptide - NP_064363
swissprot - A0A286YD19
swissprot - Q9JLJ1
Ensembl - ENSMUSG00000042682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selenokENSDARG00000100823Danio rerio
 SELENOKENSGALG00000005391Gallus gallus
 Q9Y6D0ENSG00000113811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024491  Selenoprotein SelK/SelG


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0010742 macrophage derived foam cell differentiation IMP
 biological_processGO:0018345 protein palmitoylation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IBA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0045728 respiratory burst after phagocytosis IMP
 biological_processGO:0050848 regulation of calcium-mediated signaling IMP
 biological_processGO:0051223 regulation of protein transport IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0090197 positive regulation of chemokine secretion IMP
 biological_processGO:2000406 positive regulation of T cell migration IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ush1ctm1a(KOMP)Wtsi/Ush1ctm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Ush1ctm1a(KOMP)Wtsi/Wtsi

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ier3tm1Mxw/Ier3tm1Mxw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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