Manteia - Molecule gene

ENSMUSG00000042705

Mus musculus

Features

Gene ID:	ENSMUSG00000042705

Biological name :	Commd10

Synonyms :	Commd10 / COMM domain-containing protein 10 / Q8JZY2

Possible biological names infered from orthology :	COMM domain containing 10 / Q9Y6G5

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	C
Gene start:	46958862
Gene end:	47087992

Corresponding Affymetrix probe sets:	10455578 (MoGene1.0st) 1428491_at (Mouse Genome 430 2.0 Array) 1456236_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000041650 NCBI entrez gene - 69456 See in Manteia. MGI - MGI:1916706 RefSeq - XM_006526229 RefSeq - NM_178377 RefSeq - XM_006526225 RefSeq - XM_006526226 RefSeq - XM_006526228 RefSeq - XM_006526224 RefSeq Peptide - NP_848464 swissprot - Q3TKN7 swissprot - Q8JZY2 Ensembl - ENSMUSG00000042705

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
COMMD10	ENSGALG00000002308	Gallus gallus
Q9Y6G5	ENSG00000145781	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR017920	COMM domain
IPR037361	COMM domain-containing protein 10

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0008150	biological_process	ND
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0003674	molecular_function	ND

Pathways (from Reactome)

Pathway description

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bcor^tm1Vjba/Y,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * CBA/Ca
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptpn11^tm1Ckq/Ptpn11⁺,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000248	macrocytosis	"condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Ptpn11^tm1Ckq/Ptpn11⁺,Tg(Lck-cre)1Cwi/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Ager^tm1Lex/Ager^tm1Lex Genetic Background: involves: 129S5/SvEvBrd
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Ager^tm1Lex/Ager^tm1Lex Genetic Background: involves: 129S5/SvEvBrd
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed Genetic Background: involves: 129 * C57BL/6 * FVB/N Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0000716	abnormal immune system cell morphology	"anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Egln1^tm1.1Fsl/Egln1⁺,Hif1a^tm3.1Rsjo/Hif1a⁺ Genetic Background: B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0001585	hemolytic anemia	"an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/10 * CBA/Ca
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/10 * CBA/Ca
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Chat^tm1Mlt/Chat^tm1Mlt,Tg(SLC18A3-cre)KMisa/0 Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Cd40lg^tm1Parl/Y,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Cdkn1a^tm1Led/Cdkn1a^tm1Led,Zbtb17^tm1Cksn/Zbtb17^tm1Cksn,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Zbtb17^tm1Cksn Cdkn1a^tm1Led Commd10^{Tg(Vav1-icre)A2Kio}
MP:0001879	abnormal lymphatic vessel morphology	"malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/10 * CBA/Ca Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns,Tg(Tie1-cre)9Ref/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0001993	abnormal blinking		Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Gt(ROSA)26Sor^{tm2(CARD11L225LI)Jrld}/Gt(ROSA)26Sor⁺ Genetic Background:* involves: 129P2/OlaHsd
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd44^tm1Mak/Cd44^tm1Mak Genetic Background: B6.129P2-Cd44^tm1Mak Allelic Composition: Tg(KitD814V)3Roer/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Flnb^tm1Vshn/Flnb^tm1Vshn Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Egln1^tm1.1Fsl/Egln1⁺,Hif1a^tm3.1Rsjo/Hif1a⁺ Genetic Background: B6.Cg-Egln1^tm1.1Fsl Hif1a^tm3.1Rsjo
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-PSTPIP1)Dtg}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Snai1^tm1.1Stjw/Snai1^tm1.1Stjw,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Snai1^tm1.1Stjw Commd10^{Tg(Vav1-icre)A2Kio}
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	"anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrig2^tm1.1Hhed/Lrig2^tm1.1Hhed Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw,Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
MP:0002410	decreased susceptibility to viral infection	"reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Commd10^{Tg(Vav1-icre)A2Kio}/?,Tnfrsf14^tm1.1Kro/Tnfrsf14^tm1.1Kro Genetic Background: involves: C57BL/6NCrl * C57BL/10 * CBA * SJL
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}
MP:0002413	abnormal megakaryoblast morphology/development	"anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0002416	abnormal proerythroblast morphology/development	"anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0002463	abnormal neutrophil physiology	"abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0002491	decreased IgD	"less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zfp318^tm1.1Jhws/Zfp318^tm1.1Jhws,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Zfp318^tm1.1Jhws Tg^Vav1-creA2Kio
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zfp318^tm1.1Jhws/Zfp318^tm1.1Jhws,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Zfp318^tm1.1Jhws Tg^Vav1-creA2Kio
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0002608	increased hematocrit	"greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio} Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0002810	microcytic anemia	"anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0002812	spherocytosis	"the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0002872	polycythemia	"an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio}
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0003135	increased erythrocyte precursors	"greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio} Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Cd40lg^tm1Parl/Cd40lg^tm1Parl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Cd40lg^tm1Parl/Y,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
MP:0003447	reduced tumor growth/size	"less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]	Show Allelic Composition: Dll1^tm1Gos/Dll1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003644	thymus atrophy	"wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0003656	abnormal erythrocyte physiology	"functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0003657	abnormal erythrocyte lysis	"increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0004809	increased hematopoietic stem cell number	"greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Idh1^tm1Mak/Idh1^tm1Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Idh1^tm2Mak/Idh1^tm2Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0004816	abnormal class switch recombination	"anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw,Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0004973	increased regulatory T cell number	"greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0005011	increased eosinophil count	"greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw,Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0005065	abnormal neutrophil morphology	"structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kmt5b^tm1.1Jnw/Kmt5b^tm1.1Jnw,Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
MP:0005399	increased susceptibility to fungal infection	"greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0005462	abnormal mast cell morphology/development	"anomalous structure, development or number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Atp1a3^tm1.1Kwk/Atp1a3⁺ Genetic Background: B6JJcl.Cg-Atp1a3^tm1.1Kwk
MP:0005505	increased platelet count	"greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0005561	increased mean corpuscular hemoglobin	"greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Egln1^tm2.1Fsl/Egln1^tm2.1Fsl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Egln1^tm2.1Fsl Commd10^{Tg(Vav1-icre)A2Kio} Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Pltp^tm2.1Jia/Pltp^tm2.1Jia Genetic Background: involves: C57BL/6J
MP:0005637	abnormal iron homeostasis	"anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0005642	decreased mean corpuscular hemoglobin concentration	"less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Idh1^tm1Mak/Idh1^tm1Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Idh1^tm2Mak/Idh1^tm2Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0006413	increased T cell apoptosis	"increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0008124	decreased plasmacytoid dendritic cell number	"reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]	Show Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008192	abnormal germinal center B cell physiology	"abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dag1^tm2Kcam/Dag1^tm2Kcam,Tg(Mpz-cre)26Mes/0 Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2a^tm1.1Brad/Kmt2a^tm1.1Brad Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0008249	abnormal common lymphocyte progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Idh1^tm1Mak/Idh1^tm1Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Idh1^tm2Mak/Idh1^tm2Mak,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008254	increased megakaryocyte cell number	"greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008347	decreased gamma-delta T cell number	"reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0008388	hypochromic microcytic anemia	"hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jak2^tm1.2Ble/Jak2⁺,Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008474	absent spleen germinal center	"absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008475	intermingled spleen red and white pulp	"no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0008477	decreased spleen red pulp amount	"reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008499	increased IgG1 level	"greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd40lg^tm1Parl/Cd40lg^tm1Parl,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Cd40lg^tm1Parl/Y,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0008574	decreased circulating interferon-alpha level	"reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]	Show Allelic Composition: Bcl11a^tm1Pwt/Bcl11a^tm1Pwt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Atp1a3^tm1.1Kwk/Atp1a3⁺ Genetic Background: B6JJcl.Cg-Atp1a3^tm1.1Kwk
MP:0008719	impaired neutrophil recruitment	"reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0008720	impaired neutrophil migration	"defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pepd^dal/Pepd^dal Genetic Background: involves: CAST/EiJ * CBA/J
MP:0008760	abnormal immunoglobulin heavy chain V(D)J recombination	"any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1.2Mbu,Tg(Aicda-cre)9Mbu/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2a^tm1.1Brad/Kmt2a^tm1.1Brad Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0008826	abnormal splenic cell ratio	"deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0008998	decreased blood osmolality	"decrease in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0009278	abnormal bone marrow cell physiology	"any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2a^tm1Brad/Kmt2a^tm1Brad,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
MP:0009338	increased splenocyte number	"increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
MP:0009788	increased susceptibility to bacterial infection induced morbidity/mortality	"increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}
MP:0009926	decreased transitional stage T2 B cell number	"reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]	Show Allelic Composition: Zfp318^tm1.1Jhws/Zfp318^tm1.1Jhws,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: B6.Cg-Zfp318^tm1.1Jhws Tg^Vav1-creA2Kio
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0010130	decreased DN1 thymic pro-T cell number	"reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010132	decreased DN2 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010134	decreased DN3 thymocyte number	"reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]	Show Allelic Composition: Notch1^sot/Notch1^sot Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/NJ
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atg7^tm1Tchi/Atg7^tm1Tchi,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0010766	abnormal NK cell physiology	"any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]	Show Allelic Composition: Myd88^tm1Defr/Myd88^tm1Defr,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Etv2,-GFP)Hkata}/Gt(ROSA)26Sor⁺,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
MP:0011178	increased erythroblast number	"greater number of the nucleated precursor of erythrocytes" [MGI:csmith]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0011179	decreased erythroblast number	"reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0011182	decreased hematopoietic cell number	"fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]	Show Allelic Composition: Kitl^tm2.1Sjm/Kitl^tm2.1Sjm,Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
MP:0011285	increased circulating erythropoietin level	"greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]	Show Allelic Composition: Picalm^tm1.1Tmae/Picalm^tm1.1Tmae,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
MP:0011746	spleen fibrosis	"invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0011747	myelofibrosis	"appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]	Show Allelic Composition: Tg(JAK2V617F)FF1Rsko/0,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background:* involves: C57BL/6 * C57BL/10 * CBA/Ca
MP:0012328	decreased circulating factor VIII level	"reduced levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin" [MeSH:D12.776.124.125.350, MPD:Molly]	Show Allelic Composition: Clec4n^tm1Yiw/Clec4n^tm1Yiw Genetic Background: involves: 129P2/OlaHsd
MP:0012384	abnormal erythrocyte ion transport	"aberrant measurable or observable characteristic related to the movement in red blood cells of atoms carrying an electric charge" [MPD:Molly]	Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0012664	decreased circulating haptoglobin level		Show Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: C57BL/6 * C57BL/10 * CBA
MP:0013662	decreased myeloid cell number	"reduction in the expected number of cells of the myeloid lineage" [CL:0000763]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0013693	abnormal hemopoiesis	"any anomaly in the process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure; the site of hemopoiesis is variable during development, but occurs primarily in bone marrow in mammals" [GO:0030097]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
MP:0013697	decreased granulocyte monocyte progenitor cell number	"reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0013704	increased megakaryocyte-erythroid progenitor cell number	"increase in the number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]	Show Allelic Composition: Dhx36^tm1.2Pmt/Dhx36^tm1.2Pmt,Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
MP:0013892	increased common lymphocyte progenitor cell number	"increased number of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]	Show Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon,Commd10^{Tg(Vav1-icre)A2Kio}/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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