ENSMUSG00000042757


Mus musculus

Features
Gene ID: ENSMUSG00000042757
  
Biological name :Tmem108
  
Synonyms : Mus musculus transmembrane protein 108 (Tmem108), transcript variant 2, mRNA. / Q8BHE4 / Tmem108
  
Possible biological names infered from orthology : Q6UXF1 / transmembrane protein 108
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 103482947
Gene end: 103761837
  
Corresponding Affymetrix probe sets: 10596200 (MoGene1.0st)   1436916_at (Mouse Genome 430 2.0 Array)   1454729_at (Mouse Genome 430 2.0 Array)   1459210_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046021
Ensembl peptide - ENSMUSP00000140027
Ensembl peptide - ENSMUSP00000141160
Ensembl peptide - ENSMUSP00000149890
NCBI entrez gene - 81907     See in Manteia.
MGI - MGI:1932411
RefSeq - XM_006511869
RefSeq - NM_001359465
RefSeq - NM_178638
RefSeq - XM_006511865
RefSeq - XM_006511866
RefSeq - XM_006511867
RefSeq - XM_006511868
RefSeq - XM_006511863
RefSeq - XM_006511864
RefSeq Peptide - NP_001346394
RefSeq Peptide - NP_848753
swissprot - Q8BHE4
swissprot - A0A1L1SSF6
Ensembl - ENSMUSG00000042757
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem108ENSDARG00000090230Danio rerio
 TMEM108ENSGALG00000036412Gallus gallus
 Q6UXF1ENSG00000144868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031508  Transmembrane protein 108


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0008090 retrograde axonal transport IDA
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0097106 postsynaptic density organization IMP
 biological_processGO:0097484 dendrite extension IMP
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IMP
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0002635 reduced sensorimotor gating 
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm1b(EUCOMM)Wtsi/Thra+
Genetic Background: C57BL/6N-Thratm1b(EUCOMM)Wtsi/Ics

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

 MP:0020335 abnormal dentate gyrus neuron dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron in one of two interlocking gyri of the hippocampus formation" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Rpl13atm1.1Jesc/Rpl13atm1.1Jesc
Genetic Background: FVB.129S5(Cg)-Rpl13atm1.1Jesc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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