ENSMUSG00000043207


Mus musculus

Features
Gene ID: ENSMUSG00000043207
  
Biological name :Zmpste24
  
Synonyms : Q80W54 / zinc metallopeptidase, STE24 / Zmpste24
  
Possible biological names infered from orthology : O75844
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 121059237
Gene end: 121098241
  
Corresponding Affymetrix probe sets: 10516007 (MoGene1.0st)   10516020 (MoGene1.0st)   1427923_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122588
Ensembl peptide - ENSMUSP00000053900
NCBI entrez gene - 230709     See in Manteia.
MGI - MGI:1890508
RefSeq - NM_172700
RefSeq - XM_006503019
RefSeq Peptide - NP_766288
swissprot - I7HIP5
swissprot - B9EHY2
swissprot - Q80W54
Ensembl - ENSMUSG00000043207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zmpste24ENSDARG00000044090Danio rerio
 ZMPSTE24ENSGALG00000000855Gallus gallus
 O75844ENSG00000084073Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001915  Peptidase M48
 IPR027057  CAAX prenyl protease 1
 IPR032456  CAAX prenyl protease 1, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006998 nuclear envelope organization IMP
 biological_processGO:0030327 prenylated protein catabolic process IDA
 biological_processGO:0071586 CAAX-box protein processing IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IBA
 molecular_functionGO:0004222 metalloendopeptidase activity IMP
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000469 abnormal esophageal squamous epithelium morphology "malformation of the scaly epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001221 epidermal atrophy "wasting of the epidermal layer of the skin" [J:65033]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gja1tm3(Gja5)Kwi/Gja1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm1Stw/Lmnatm1Stw,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0003795 abnormal bone structure 
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0004548 dilated esophagus "an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004675 rib fractures "a crack or break in the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005270 abnormal zygomatic bone morphology "anomalous structure of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: B6.129S4-Zmpste24tm1Sgy

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Lmnatm6Lgf/Lmna+,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0009480 distended cecum "an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0009878 decreased susceptibility to bone fracture "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmnatm6Lgf/Lmnatm6Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0011009 increased circulating glutamate dehydrogenase level "increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129S4/SvJae

 MP:0011570 esophageal achalasia "failure of the normal relaxation of the lower esophageal sphincter associated with the uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction" [ISBN:0-683-40008-8]
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Allelic Composition: Lmnatm10Lgf/Lmnatm10Lgf,Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0030082 long lower incisors "increased length or overgrowth of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Lmnatm1Stw/Lmnatm2Lgf
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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