ENSMUSG00000043252


Mus musculus

Features
Gene ID: ENSMUSG00000043252
  
Biological name :Tmem64
  
Synonyms : Q3U145 / Tmem64 / Transmembrane protein 64
  
Possible biological names infered from orthology : Q6YI46
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A2
Gene start: 15265831
Gene end: 15286753
  
Corresponding Affymetrix probe sets: 10503410 (MoGene1.0st)   1433735_a_at (Mouse Genome 430 2.0 Array)   1434307_at (Mouse Genome 430 2.0 Array)   1454709_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055892
NCBI entrez gene - 100201     See in Manteia.
MGI - MGI:2140359
RefSeq - NM_181401
RefSeq Peptide - NP_852066
swissprot - Q3U145
Ensembl - ENSMUSG00000043252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem64ENSDARG00000061723Danio rerio
 TMEM64ENSGALG00000042599Gallus gallus
 Q6YI46ENSG00000180694Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015414  Transmembrane protein TMEM64
 IPR032816  SNARE associated Golgi protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043462 regulation of ATPase activity IMP
 biological_processGO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IMP
 biological_processGO:0045672 positive regulation of osteoclast differentiation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0003795 abnormal bone structure 
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0011710 increased osteoblast differentiation 
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
Show

Allelic Composition: Spi1tm4.1Dgt/Spi1tm4.1Dgt
Genetic Background: B6.129(Cg)-Spi1tm4.1Dgt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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