ENSMUSG00000043289


Mus musculus

Features
Gene ID: ENSMUSG00000043289
  
Biological name :Mei4
  
Synonyms : Mei4 / Mus musculus meiotic double-stranded break formation protein 4 (Mei4), transcript variant 2, mRNA. / Q8BRM6
  
Possible biological names infered from orthology : A8MW99 / meiotic double-stranded break formation protein 4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 81863670
Gene end: 82206007
  
Corresponding Affymetrix probe sets: 10587488 (MoGene1.0st)   1437935_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061341
Ensembl peptide - ENSMUSP00000139589
Ensembl peptide - ENSMUSP00000140647
NCBI entrez gene - 75033     See in Manteia.
MGI - MGI:1922283
RefSeq - XM_006511521
RefSeq - NM_001357477
RefSeq - NM_175213
RefSeq Peptide - NP_001344406
RefSeq Peptide - NP_780422
swissprot - Q8BRM6
swissprot - A0A087WP18
Ensembl - ENSMUSG00000043289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mei4ENSDARG00000043912Danio rerio
 MEI4ENSGALG00000041938Gallus gallus
 MEI4ENSG00000269964Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025888  Meiosis-specific protein MEI4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0042138 meiotic DNA double-strand break formation IEA
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009205 abnormal internal male genitalia morphology "any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009361 abnormal primordial ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009362 abnormal primary ovarian follicle morphology "any structural abnormality in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009451 abnormal chromosome pairing during meiosis "an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: a/a,Tyrp1b/Tyrp1b,wad/wad
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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