ENSMUSG00000043445


Mus musculus

Features
Gene ID: ENSMUSG00000043445
  
Biological name :Pgp
  
Synonyms : Glycerol-3-phosphate phosphatase / Pgp / Q8CHP8
  
Possible biological names infered from orthology : A6NDG6 / phosphoglycolate phosphatase
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24470473
Gene end: 24471591
  
Corresponding Affymetrix probe sets: 10442454 (MoGene1.0st)   1428788_at (Mouse Genome 430 2.0 Array)   1452919_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052866
NCBI entrez gene - 67078     See in Manteia.
MGI - MGI:1914328
RefSeq - NM_025954
RefSeq Peptide - NP_080230
swissprot - Q8CHP8
Ensembl - ENSMUSG00000043445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgpENSDARG00000029695Danio rerio
 PGPENSGALG00000005888Gallus gallus
 PGPENSG00000184207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdxp / P60487 / Pyridoxal phosphate phosphatase / Q96GD0* / pyridoxal phosphatase*ENSMUSG0000011616542


Protein motifs (from Interpro)
Interpro ID Name
 IPR006349  2-phosphoglycolate phosphatase, eukaryotic
 IPR006357  HAD-superfamily hydrolase, subfamily IIA
 IPR023214  HAD superfamily
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006114 glycerol biosynthetic process IDA
 biological_processGO:0006650 glycerophospholipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IDA
 biological_processGO:0045721 negative regulation of gluconeogenesis IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000121 glycerol-1-phosphatase activity IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008967 phosphoglycolate phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0043136 glycerol-3-phosphatase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0098519 nucleotide phosphatase activity, acting on free nucleotides IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011702 abnormal fibroblast proliferation "anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Sh3bp2tm1c(KOMP)Wtsi/Sh3bp2tm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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