ENSMUSG00000043505


Mus musculus

Features
Gene ID: ENSMUSG00000043505
  
Biological name :Gimap5
  
Synonyms : Gimap5 / GTPase IMAP family member 5 / Q8BWF2
  
Possible biological names infered from orthology : GIMAP1-GIMAP5 / GIMAP1-GIMAP5 readthrough / Q96F15
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.3
Gene start: 48746197
Gene end: 48754210
  
Corresponding Affymetrix probe sets: 10538142 (MoGene1.0st)   1444181_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056820
NCBI entrez gene - 317757     See in Manteia.
MGI - MGI:2442232
RefSeq - XM_017321618
RefSeq - NM_175035
RefSeq - XM_006506231
RefSeq - XM_006506232
RefSeq - XM_006506228
RefSeq - XM_006506230
RefSeq Peptide - NP_778200
swissprot - Q8BWF2
Ensembl - ENSMUSG00000043505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL953865.1ENSDARG00000109438Danio rerio
 BX004816.1ENSDARG00000040497Danio rerio
 BX569789.1ENSDARG00000099678Danio rerio
 CABZ01049362.1ENSDARG00000099508Danio rerio
 CABZ01059407.1ENSDARG00000115164Danio rerio
 CABZ01059408.1ENSDARG00000116928Danio rerio
 CR388047.1ENSDARG00000090015Danio rerio
 CR774195.1ENSDARG00000078832Danio rerio
 FO680692.1ENSDARG00000109228Danio rerio
 FP326649.2ENSDARG00000117179Danio rerio
 LO018551.1ENSDARG00000115941Danio rerio
 LO018605.1ENSDARG00000093082Danio rerio
 si:ch1073-185p12.2ENSDARG00000100199Danio rerio
 si:ch1073-322p19.1ENSDARG00000075173Danio rerio
 si:ch211-113e8.5ENSDARG00000069707Danio rerio
 si:ch211-113e8.6ENSDARG00000074610Danio rerio
 si:ch211-229i14.2ENSDARG00000086048Danio rerio
 si:ch73-285p12.4ENSDARG00000054548Danio rerio
 si:ch73-308m11.1ENSDARG00000039752Danio rerio
 si:dkey-125e8.4ENSDARG00000041333Danio rerio
 si:dkey-1c7.3ENSDARG00000074205Danio rerio
 si:dkey-73p2.1ENSDARG00000095739Danio rerio
 si:dkey-73p2.2ENSDARG00000079245Danio rerio
 si:dkey-73p2.3ENSDARG00000095076Danio rerio
 si:dkey-88j15.3ENSDARG00000076573Danio rerio
 si:dkey-88j15.4ENSDARG00000079471Danio rerio
 si:dkeyp-52c3.5ENSDARG00000038392Danio rerio
 si:dkeyp-67a8.4ENSDARG00000092823Danio rerio
 si:dkeyp-67a8.4ENSDARG00000090099Danio rerio
 zgc:113625ENSDARG00000054160Danio rerio
 zgc:152658ENSDARG00000018587Danio rerio
 zgc:153642ENSDARG00000052900Danio rerio
 zgc:171452ENSDARG00000074069Danio rerio
 zgc:172091ENSDARG00000103058Danio rerio
 zgc:194443ENSDARG00000078182Danio rerio
 GIMAP1-GIMAP5ENSG00000281887Homo sapiens
 GIMAP5ENSG00000196329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99MI6 / Gimap3 / GTPase IMAP family member 3 / GIMAP5* / Q96F15* / GIMAP1-GIMAP5* / GIMAP1-GIMAP5 readthrough* / GTPase, IMAP family member 5*ENSMUSG0000003926480
Gimap1 / GTPase, IMAP family member 1 / Q8WWP7*ENSMUSG0000009001935
Gimap7 / Q8NHV1* / GTPase, IMAP family member 7*ENSMUSG0000004393134
Gimap6 / Q8K349 / GTPase IMAP family member 6 / Q6P9H5*ENSMUSG0000004786731
Gimap4 / Q99JY3 / GTPase IMAP family member 4 / Q9NUV9*ENSMUSG0000005443531
Gimap9 / GIMAP7* / Q8NHV1* / GTPase, IMAP family member 7*ENSMUSG0000005112430
Gimap8 / Q75N62 / GTPase IMAP family member 8 / Q8ND71*ENSMUSG0000006426229


Protein motifs (from Interpro)
Interpro ID Name
 IPR006703  AIG1-type guanine nucleotide-binding (G) domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: either: (involves: BALB/cJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J) or (C57BL/6J * DBA/2J) or (involves: C57BL/6J * FVB/NJ) or (involves: C57BL/6J * NOD/ShiLtJ)

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Hsd17b7tm1Mpo/Hsd17b7tm1Mpo
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: either: (involves: BALB/cJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J) or (C57BL/6J * DBA/2J) or (involves: C57BL/6J * FVB/NJ) or (involves: C57BL/6J * NOD/ShiLtJ)

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: either: (involves: BALB/cJ * C57BL/6J) or (involves: C3H/HeN * C57BL/6J) or (C57BL/6J * DBA/2J) or (involves: C57BL/6J * FVB/NJ) or (involves: C57BL/6J * NOD/ShiLtJ)

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0005563 abnormal hemoglobin content "deviation from the normal total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abl1tm1Mlg/Abl1tm1Mlg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Gimap5m1Btlr/Gimap5m1Btlr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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