ENSMUSG00000043991


Mus musculus

Features
Gene ID: ENSMUSG00000043991
  
Biological name :Pura
  
Synonyms : P42669 / Pura / Transcriptional activator protein Pur-alpha
  
Possible biological names infered from orthology : purine rich element binding protein A / Q00577
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B2
Gene start: 36281097
Gene end: 36289723
  
Corresponding Affymetrix probe sets: 10454877 (MoGene1.0st)   1420628_at (Mouse Genome 430 2.0 Array)   1438219_at (Mouse Genome 430 2.0 Array)   1449934_at (Mouse Genome 430 2.0 Array)   1453783_at (Mouse Genome 430 2.0 Array)   1456898_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059404
NCBI entrez gene - 19290     See in Manteia.
MGI - MGI:103079
RefSeq - XM_011246860
RefSeq - NM_008989
RefSeq - XM_006525724
RefSeq Peptide - NP_033015
swissprot - P42669
Ensembl - ENSMUSG00000043991
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 puraaENSDARG00000067591Danio rerio
 purabENSDARG00000099614Danio rerio
 PURAENSGALG00000029387Gallus gallus
 PURAENSG00000185129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Purb / O35295 / purine rich element binding protein B / Q96QR8*ENSMUSG0000009448367
Purg / Q8R4E6 / Purine-rich element-binding protein gamma / Q9UJV8* / purine rich element binding protein G*ENSMUSG0000004918451


Protein motifs (from Interpro)
Interpro ID Name
 IPR006628  Purine-rich element binding protein family
 IPR030500  Purine-rich element-binding protein alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006268 DNA unwinding involved in DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007093 mitotic cell cycle checkpoint NAS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005662 DNA replication factor A complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0000900 translation repressor activity, mRNA regulatory element binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0032422 purine-rich negative regulatory element binding IDA
 molecular_functionGO:0046332 SMAD binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Kkh/Pura+
Genetic Background: involves: 129

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000778 abnormal tract 
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000851 cerebellum hypoplasia "reduced cell number in the cerebellum" [MGI:CLS, J:45302]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Puratm1Kkh/Pura+
Genetic Background: involves: 129

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Kkh/Pura+
Genetic Background: involves: 129

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Puratm1Herm/Pura+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004097 abnormal cerebellar cortex morphology "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

Allelic Composition: Puratm1Kkh/Pura+
Genetic Background: involves: 129

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008941 reticulocytopenia "decrease in the normal number of circulating reticulocytes" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Puratm1Herm/Pura+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010897 abnormal bronchiole epithelium morphology "any structural anomaly of the epithelial layer of the bronchioles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps-2J/Gusbmps-2J
Genetic Background: C3H/HeOuJ-Gusbmps-2J/BrkJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011149 abnormal hippocampus stratum lacunosum morphology 
Show

Allelic Composition: Puratm1Herm/Puratm1Herm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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