ENSMUSG00000044433


Mus musculus

Features
Gene ID: ENSMUSG00000044433
  
Biological name :Camsap3
  
Synonyms : Calmodulin-regulated spectrin-associated protein 3 / Camsap3 / Q80VC9
  
Possible biological names infered from orthology : calmodulin regulated spectrin associated protein family member 3 / Q9P1Y5
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 3587293
Gene end: 3609075
  
Corresponding Affymetrix probe sets: 10569830 (MoGene1.0st)   1432464_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147209
Ensembl peptide - ENSMUSP00000147126
Ensembl peptide - ENSMUSP00000147231
Ensembl peptide - ENSMUSP00000058958
Ensembl peptide - ENSMUSP00000125993
Ensembl peptide - ENSMUSP00000146359
Ensembl peptide - ENSMUSP00000146565
Ensembl peptide - ENSMUSP00000146772
Ensembl peptide - ENSMUSP00000146852
Ensembl peptide - ENSMUSP00000146896
NCBI entrez gene - 69697     See in Manteia.
MGI - MGI:1916947
RefSeq - XM_006508881
RefSeq - NM_027171
RefSeq - XM_006508874
RefSeq - XM_006508875
RefSeq - XM_006508876
RefSeq - XM_006508877
RefSeq - XM_006508878
RefSeq - XM_006508879
RefSeq - XM_006508880
RefSeq - NM_001163749
RefSeq Peptide - NP_081447
RefSeq Peptide - NP_001334040
RefSeq Peptide - NP_001334041
RefSeq Peptide - NP_001334042
RefSeq Peptide - NP_001157221
swissprot - Q80VC9
swissprot - A0A140LJ93
swissprot - A0A140LJI9
Ensembl - ENSMUSG00000044433
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01118678.1ENSDARG00000091359Danio rerio
 camsap3ENSDARG00000059475Danio rerio
 Q9P1Y5ENSG00000076826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C1B1 / Camsap2 / Calmodulin-regulated spectrin-associated protein 2 / Q08AD1* / calmodulin regulated spectrin associated protein family member 2*ENSMUSG0000004157040
A2AHC3 / Camsap1 / Calmodulin-regulated spectrin-associated protein 1 / Q5T5Y3*ENSMUSG0000002693335


Protein motifs (from Interpro)
Interpro ID Name
 IPR011033  PRC-barrel-like superfamily
 IPR014797  CKK domain
 IPR022613  Calmodulin-regulated spectrin-associated protein, CH domain
 IPR031372  CAMSAP, spectrin and Ca2+/calmodulin-binding region
 IPR032940  Calmodulin-regulated spectrin-associated protein
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0009792 embryo development ending in birth or egg hatching IDA
 biological_processGO:0010923 negative regulation of phosphatase activity ISS
 biological_processGO:0030334 regulation of cell migration ISS
 biological_processGO:0030951 establishment or maintenance of microtubule cytoskeleton polarity ISO
 biological_processGO:0031113 regulation of microtubule polymerization ISO
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033043 regulation of organelle organization IGI
 biological_processGO:0034453 microtubule anchoring ISS
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity ISS
 biological_processGO:0045218 zonula adherens maintenance ISO
 biological_processGO:0051893 regulation of focal adhesion assembly ISO
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISO
 biological_processGO:0090136 epithelial cell-cell adhesion ISS
 biological_processGO:0098840 protein transport along microtubule IDA
 biological_processGO:1903358 regulation of Golgi organization ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005915 zonula adherens ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0036449 microtubule minus-end ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0051011 microtubule minus-end binding ISO
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0008922 abnormal cervical rib "alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0008986 abnormal liver parenchyma morphology "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cfap69tm1c(KOMP)Wtsi/Cfap69tm1c(KOMP)Wtsi,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
Show

Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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