ENSMUSG00000044562


Mus musculus

Features
Gene ID: ENSMUSG00000044562
  
Biological name :Rasip1
  
Synonyms : Q3U0S6 / Ras-interacting protein 1 / Rasip1
  
Possible biological names infered from orthology : Q5U651
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45627488
Gene end: 45639093
  
Corresponding Affymetrix probe sets: 10553042 (MoGene1.0st)   1428016_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062429
NCBI entrez gene - 69903     See in Manteia.
MGI - MGI:1917153
RefSeq - NM_028544
RefSeq Peptide - NP_082820
swissprot - Q3U0S6
Ensembl - ENSMUSG00000044562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rasip1ENSDARG00000074829Danio rerio
 Q5U651ENSG00000105538Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Radil / Q69Z89 / Ras-associating and dilute domain-containing protein / Q96JH8* / Rap associating with DIL domain*ENSMUSG0000002957630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR002710  Dilute domain
 IPR008984  SMAD/FHA domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0043087 regulation of GTPase activity IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017016 Ras GTPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0003543 abnormal vascular endothelial cell differentiation "anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi

Allelic Composition: Rasip1tm1.1Wye/Rasip1tm1.1Wye
Genetic Background: C57BL/6-Rasip1tm1.1Wye

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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