ENSMUSG00000044715


Mus musculus

Features
Gene ID: ENSMUSG00000044715
  
Biological name :Gskip
  
Synonyms : GSK3B-interacting protein / Gskip / Q8BGR8
  
Possible biological names infered from orthology : Q9P0R6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 105684829
Gene end: 105703023
  
Corresponding Affymetrix probe sets: 10398124 (MoGene1.0st)   1431334_a_at (Mouse Genome 430 2.0 Array)   1433700_at (Mouse Genome 430 2.0 Array)   1435422_at (Mouse Genome 430 2.0 Array)   1435423_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152722
Ensembl peptide - ENSMUSP00000057939
NCBI entrez gene - 66787     See in Manteia.
MGI - MGI:1914037
RefSeq - NM_178613
RefSeq Peptide - NP_848728
swissprot - A0A1Y7VNZ5
swissprot - Q3TBR1
swissprot - Q8BGR8
Ensembl - ENSMUSG00000044715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gskipENSDARG00000038099Danio rerio
 GSKIPENSGALG00000011088Gallus gallus
 GSKIPENSG00000100744Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007967  GSKIP domain
 IPR023231  GSKIP domain superfamily
 IPR037395  GSK3B-interacting protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress ISS
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0051018 protein kinase A binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0003756 abnormal hard palate "abnormality in the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
Show

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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